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Waste milk consumption in dairy calves: Effects on innate immunity and inflammatory profile.

Vet Immunol Immunopathol

January 2025

Department of Internal Medicine, College of Veterinary Medicine and Animal Science, University of Sao Paulo, São Paulo, Brazil. Electronic address:

Waste milk (WM) is commonly used in calf feeding to reduce rearing costs; however, its effects on the innate immune response remain unexplored. Therefore, this study aimed to evaluate the effects of WM on the innate immune response and inflammatory profile of pre-weaned dairy calves. Thirty male Holstein calves were assigned to receive pasteurized waste milk (PWM), saleable milk (SM), and WM (n = 10 in each group).

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Candidate Tear-Based Uveitis Biomarkers in Children with JIA Based on Arthritis Activity and Topical Corticosteroid Use.

Ocul Immunol Inflamm

November 2024

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.

Background: Uveitis is an inflammatory ocular disease secondary to disruption of the retinal pigmented epithelium (RPE) and blood retinal barrier (BRB). Known clinical factors do not accurately predict uveitis risk in Juvenile Idiopathic Arthritis (JIA). Tear fluid is easily obtained for biomarker study.

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Serum zonulin and colorectal cancer risk.

Sci Rep

November 2024

Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, University of Milan, Milan, Italy.

Intestinal permeability has been related to colorectal cancer (CRC) development. Zonulin, a protein able to regulate tight junction function and intestinal permeability, emerges as a promising marker to elucidate the contribution of bacterial translocation in CRC. An Italian case-control study included 77 CRC cases, 72 intestinal adenoma and 76 healthy controls (for a total of 148 tumor-free subjects), aged 20-85.

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An immuno-inflammatory profiling of asymptomatic individuals in a malaria endemic area in Uganda.

Acta Trop

December 2024

Department of Laboratory medicine, Lund University, Lund, Sweden; Clinical Chemistry and Pharmacology, Office for Medical Services, Region Skåne, Lund, Sweden. Electronic address:

Malaria caused by Plasmodium falciparum leads to the destruction of red blood cells (RBCs). A better understanding of how naturally immune individuals control infections should be valuable for future vaccine studies. Antibodies against RBCs and RBC surface antigens were measured together with different inflammatory markers in healthy adults living in a malaria endemic area of Uganda and compared to Swedish healthy adults.

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Article Synopsis
  • Vitamin E is an essential micronutrient that may reduce cardiovascular risk in diabetes patients with the Hp 2-2 genotype, though the exact mechanism is not well understood.
  • A systematic review was conducted, examining 163 publications and ultimately including five studies with 463 participants, focusing on the effects of vitamin E on high-density lipoprotein (HDL) levels and function.
  • Results showed that while vitamin E did not significantly change HDL levels across all Hp genotypes, it appeared to enhance HDL function, specifically improving cholesterol efflux in Hp 2-2 diabetes patients, indicating a potential pharmacogenetic interaction.
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