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Kidney Function Tests and Continuous eGFR Decrease at Six Months after SARS-CoV-2 Infection in Patients Clinically Diagnosed with Post-COVID Syndrome.
Biomedicines
April 2024
Doctoral School, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
The long-term sequelae of SARS-CoV-2 infection are still under research, since extensive studies showed plenty of systemic effects of the viral infection, extending even after the acute phase of the infection. This study evaluated kidney function tests six months after SARS-CoV-2 infection in patients clinically diagnosed with Post-COVID Syndrome, hypothesizing persistent renal dysfunction evidenced by altered kidney function tests compared to baseline levels. Continuous eGFR decrease <30 at six months post-infection was considered the main study outcome.
View Article and Find Full Text PDFThrombomodulin activation driven by LXR agonist attenuates renal injury in diabetic nephropathy.
Front Med (Lausanne)
January 2023
Renal Division and Institute of Nephrology, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Objective: Inflammation and thrombosis are recognized as interrelated biological processes. Both thrombomodulin (TM) and factor XIII-A (FXIII-A) are involved in inflammation and coagulation process. However, their role in the pathogenesis of diabetic nephropathy (DN) remains unclear.
View Article and Find Full Text PDFAnalysis of Deaths and Favorable Developments of Patients with SARS-CoV-2 Hospitalized in the Largest Hospital for Infectious Diseases and Pneumo-Phthisiology in the West of the Country.
Int J Gen Med
March 2022
Department XIII, Discipline of Epidemiology, University of Medicine and Pharmacy "Victor Babes", Timisoara, 300041, Romania.
Purpose: Romania is one of the European countries that has been hit the hardest by the severe acute respiratory syndrome caused by the new coronavirus SARS-CoV-2, with over 1.91 million reported cases and over 59,257 deaths. The aim of this study was to identify the main predictors of death in hospitalized patients.
View Article and Find Full Text PDFArticle Synopsis
- The study reviews outcomes of patients receiving mechanical circulatory support in Europe from 2011 to 2020, analyzing data from 72 hospitals with over 4,800 procedures included.
- It found that in-hospital deaths and adverse events decreased significantly over three time eras, showing improvements in patient outcomes over time.
- The research highlights that patient characteristics and risks associated with early versus late-phase outcomes are time-dependent, emphasizing the importance of continuous monitoring in clinical practices.
Increased Kynurenine Indicates a Fatal Course of COVID-19.
Antioxidants (Basel)
December 2021
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.
: An inefficient immune response accompanied by an overwhelming inflammatory reaction is involved in severe courses of COVID-19. Kynurenine (KYN) has important immune-modulatory functions and may contribute to a failure in controlling SARS-CoV-2. The present study aims to explore biomarkers that hint at a fatal outcome of COVID-19 early on.
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