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Do Exercise and Magnesium Sulfate Improve Infertility Caused by Lithium Carbonate in Male Rats?
Adv Biomed Res
November 2024
Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Background: Lithium (Li) is widely used in the treatment of bipolar disorder, but it may lead to toxicity in the reproductive system. Considering the harmful effect of Li consumption on fertility and the positive effect of magnesium sulfate (MgSo) and moderate-intensity training (MIT) on improving the quality of men's sperm, the current research was conducted to determine the impact of MIT and MgSo on infertility caused by Li.
Materials And Methods: Seventy-two male rats were divided into 12 groups, control, Li10 mg/kg/day/ip, MgSo 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo; Li10+MIT; Li10+MgSo+MIT; Li40+MgSo; Li40+MIT; Li40+MgSo+MIT.
Lithium Use During Pregnancy in 14 Countries.
JAMA Netw Open
December 2024
Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Importance: In pregnancy, the benefits of lithium treatment for relapse prevention in psychiatric conditions must be weighed against potential teratogenic effects. Currently, there is a paucity of information on how and when lithium is used by pregnant women.
Objective: To examine lithium use in the perinatal period.
Methodology for Biological Sample Collection, Processing, and Storage in the Newcastle 1000 Pregnancy Cohort: Protocol for a Longitudinal, Prospective Population-Based Study in Australia.
JMIR Res Protoc
November 2024
School of Medicine and Public Health, College and Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, Australia.
Background: Research in the developmental origins of health and disease provides compelling evidence that adverse events during the first 1000 days of life from conception can impact life course health. Despite many decades of research, we still lack a complete understanding of the mechanisms underlying some of these associations. The Newcastle 1000 Study (NEW1000) is a comprehensive, prospective population-based pregnancy cohort study based in Newcastle, New South Wales, Australia, that will recruit pregnant women and their partners at 11-14 weeks' gestation, with assessments at 20, 28, and 36 weeks; birth; 6 weeks; and 6 months, in order to provide detailed data about the first 1000 days of life to investigate the developmental origins of noncommunicable diseases.
View Article and Find Full Text PDFComparative Safety of Antipsychotic Medications and Mood Stabilizers During Pregnancy: A Systematic Review and Network Meta-analysis of Congenital Malformations and Prenatal Outcomes.
CNS Drugs
January 2025
Department of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, People's Republic of China.
Background: A network meta-analysis was performed to evaluate the risk of congenital malformations and other prenatal outcomes in fetuses after exposure to antipsychotic medications and mood stabilizers during pregnancy.
Methods: We searched the PubMed, EMBASE, and Cochrane CENTRAL databases up to 15 December 2023, to identify experimental and observational studies comparing antipsychotic and mood stabilizer treatments with control treatments (no exposure). The primary outcome of the study was the incidence of congenital malformations and the secondary outcomes were preterm birth and spontaneous abortion.
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