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Introduction: White matter hyperintensities (WMHs) are an important imaging marker for cerebral small vessel diseases, but their risk factors and cognitive associations have not been well documented in populations of different ethnicities and/or from different geographical regions.
Methods: We investigated how WMHs were associated with vascular risk factors and cognition in both Whites and Asians, using data from five population-based cohorts of non-demented older individuals from Australia, Singapore, South Korea, and Sweden ( = 1946). WMH volumes (whole brain, periventricular, and deep) were quantified with UBO Detector and harmonized using the ComBat model.
Novel avenues of tau research.
Alzheimers Dement
March 2024
Alzheimer's Association, Chicago, Illinois, USA.
Introduction: The pace of innovation has accelerated in virtually every area of tau research in just the past few years.
Methods: In February 2022, leading international tau experts convened to share selected highlights of this work during Tau 2022, the second international tau conference co-organized and co-sponsored by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation.
Results: Representing academia, industry, and the philanthropic sector, presenters joined more than 1700 registered attendees from 59 countries, spanning six continents, to share recent advances and exciting new directions in tau research.
Evaluation of the Online Component of a Blended Learning Electroconvulsive Therapy Curriculum for Psychiatry Residents to Treat Depression in Older Adults.
Acad Psychiatry
February 2024
McMaster University, Hamilton, ON, Canada.
Objective: The objective of this study was to evaluate the online component of a blended curriculum for psychiatry residents on the use of electroconvulsive therapy (ECT) to treat depression in older adults.
Methods: Second- and third-year general psychiatry residents completed a blended learning curriculum during their core geriatric psychiatry rotation. The curriculum consisted of didactic seminars, hands-on clinical management, and two online clinical cases focused on the management of late-life depression with ECT.
Tau-targeting antisense oligonucleotide MAPT in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial.
Nat Med
June 2023
Ionis Pharmaceuticals, Carlsbad, CA, USA.
Article Synopsis
- Tau is a significant factor in Alzheimer's disease, and lowering tau levels may help reduce the associated pathology.
- A phase 1b clinical trial tested a tau-targeting treatment called MAPT, focusing on its safety and effectiveness in reducing tau levels in patients with mild Alzheimer's.
- Results showed that MAPT was generally safe with mild side effects, and patients receiving higher doses experienced over a 50% reduction in tau protein levels in their cerebrospinal fluid after treatment.
Evidence-oriented teaching of geriatric psychiatry: a narrative literature synthesis and pilot evaluation of a clerkship seminar.
GMS J Med Educ
June 2022
University of Bern, University Hospital of Old Age Psychiatry and Psychotherapy, Bern, Switzerland.
Introduction: The field of geriatric psychiatry has in recent decades developed into an independent discipline, incorporating elements of psychiatry, neurology and internal medicine. In view of demographic changes, this field is becoming increasingly relevant for primary care and undergraduate medical training. So far, however, there is little educational guidance for instructional design of geriatric psychiatry in undergraduate medical education.
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