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Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer.
Nat Commun
January 2025
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
The efficacy of cancer immunotherapy relies on a sufficient amount of functional immune cells. Triple-negative breast cancer lacks enough immune cell infiltration, and adjuvant therapy is necessary to prime anti-tumor immunity. However, the improvement in efficacy is unsatisfactory with concern about inducing systemic immunotoxicity.
View Article and Find Full Text PDFPreparation of nano(micro)particles from Cotinus coggygria Scop. extracts and investigation of their antimicrobial effects in vivo Caenorhabditis elegans model.
Microb Pathog
January 2025
Trakya University, Faculty of Science, Department of Biology, Department of Basic and Industrial Microbiology, Edirne, Türkiye. Electronic address:
Cotinus coggygria Scop. (Anacardiaceae) is traditionally used in Turkey for wound and burn treatment. A series of nano/micro-sized polymeric particles were prepared from aqueous and ethanol extracts of Cotinus coggygria leaves by reverse micellar microemulsion polymerization.
View Article and Find Full Text PDFEnhanced mercury deposition in Arctic Alaskan lake sediments coincides with early Holocene hydroclimate shift.
Sci Total Environ
January 2025
School of Geography and Environmental Science, University of Southampton, UK.
Substantial amounts of mercury (Hg) are projected to be released into Arctic watersheds as permafrost thaws amid warmer and wetter conditions. This may have far-reaching consequences because the highly toxic methylated form of Hg biomagnifies rapidly in ecosystems. However, understanding how climate change affects Hg dynamics in permafrost regions is limited due to the lack of long-term Arctic Hg records.
View Article and Find Full Text PDFBiofloc technology significantly reshapes water microbiome and improves survival rates in Japanese eel ().
Microbiol Spectr
January 2025
Department of Biology and Chemistry, Changwon National University, Changwon, South Korea.
Unlabelled: Global aquaculture production faces the challenge of biologically cycling nitrogenous waste. Biofloc technology (BFT) systems offer the potential to reduce water consumption and eliminate waste products by using beneficial microorganisms to convert waste into usable nutrients or non-toxic molecules. Unlike flow-through systems (FTS), which depend on continuous water exchange and result in higher operational costs as well as limited microbiome stability, BFT operates without the need for constant water exchange.
View Article and Find Full Text PDFOn how titanium dioxide nanoparticles attenuate the toxicity of mercuric chloride to : investigation of fatty acid composition, oxidative stress, and lipid peroxidation.
Nanotoxicology
January 2025
Department of Fisheries, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran.
Titanium dioxide nanoparticles (TiONPs) as an emerging pollutant in aquatic environments can interact with metals reducing or enhancing their toxicity in these environments. This study examined and compared the toxic effects of mercury ions (Hg ions) on immobilization percentage, fatty acid profile, and oxidative stress of nauplii, individually (Hg) and simultaneously in the presence of 0.10 mg.
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