The eyes of 78 patients who underwent retinal detachment microsurgery (82 eyes) were prospectively evaluated postoperatively with fluorescein angiography. Of these 14.6% showed angiographic evidence of cystoid macular oedema (CMO.). A significantly greater risk of developing cmo was discovered in aphakic eyes (30% CMO.) as compared to phakic eyes (7% CMO.) and in eyes where the maculae were detached pre-operatively (23% CMO.), as compared to eyes where the maculae were attached pre-operatively (5% CMO.). Eyes which had undergone several surgical procedures for retinal reattachment (38% CMO.) were compared to eyes which had undergone only one surgical procedure (6.5% CMO.). It was found that 4.9% of the 82 eyes showed cellophane premacular membrane without dye leakage. A further 6% of the eyes showed premacular membranes associated with dye leakage. No statistically significant risk factor associated with the development of macular pucker was disclosed in this series.
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Nat Commun
January 2025
Key Laboratory for Power Machinery and Engineering of Ministry of Education, Research Center for Renewable Synthetic Fuel, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Light-driven bioethanol dehydration offers attractive outlooks for the sustainable production of ethylene. Herein, a surface-hydrogenated CrMnO is coupled with GaN nanowires (GaN@CMO-H) for light-driven ethanol dehydration to ethylene. Through combined experimental and computational investigations, a surface hydrogen-replenishment mechanism is proposed to disclose the ethanol dehydration pathway over GaN@CMO-H.
View Article and Find Full Text PDFFront Big Data
January 2025
AI Institute, University of South Carolina, Columbia, SC, United States.
The emergence of advanced artificial intelligence (AI) models has driven the development of frameworks and approaches that focus on automating model training and hyperparameter tuning of end-to-end AI pipelines. However, other crucial stages of these pipelines such as dataset selection, feature engineering, and model optimization for deployment have received less attention. Improving efficiency of end-to-end AI pipelines requires metadata of past executions of AI pipelines and all their stages.
View Article and Find Full Text PDFBMC Med
January 2025
Health Emergencies Programme, World Health Organization, Geneva, Switzerland.
Background: Tecovirimat, an antiviral treatment for smallpox, was approved as a treatment for mpox by the European Medicines Agency in January 2022. Approval was granted under "exceptional circumstances" based on effectiveness found in pre-clinical challenge studies in animals and safety studies in humans showing minimal side effects. As clinical efficacy studies are still ongoing, there is currently limited information with regard to the acceptability of tecovirimat to treat mpox.
View Article and Find Full Text PDFNat Med
January 2025
Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France.
Continuous compensation for cerebral dopamine deficiency represents an ideal treatment for Parkinson's disease. Dopamine does not cross the digestive and blood-brain barriers and is rapidly oxidized. The new concept is the intracerebroventricular administration of anaerobic dopamine (A-dopamine) using an abdominal pump connected to a subcutaneous catheter implanted in the third ventricle, near the striatum.
View Article and Find Full Text PDFEClinicalMedicine
August 2024
Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Background: Metastatic retroperitoneal lymph node dissection (LND) for nodal recurrence is applied for a variety of cancers, such as urological, gynaecological and rectal cancer. Precise localisation and resection of these lymph nodes (LNs) during surgery can be challenging, especially after previous radiotherapy or surgery. The objective of this study was to assess the added value of surgical navigation for targeted LND in the retroperitoneum.
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