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Efficacy of Acoramidis on All-Cause Mortality and Cardiovascular Hospitalization in Transthyretin Amyloid Cardiomyopathy.
J Am Coll Cardiol
March 2025
National Amyloidosis Centre, University College London, Royal Free Hospital, London, United Kingdom.
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed chronic disease associated with progressive heart failure that results in impaired quality of life, repeated hospitalizations, and premature death. Acoramidis is a selective, oral transthyretin stabilizer recently approved by the U.S.
View Article and Find Full Text PDFA new removable connecting device for MARPE expander with non-common path of insertion.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University; Hunan Engineering Research Center for Digital Intelligence and Personalized Medicine; Hunan 3D Printing Engineering Research Center of Oral Care, Changsha 410008.
Objectives: Maxillary transverse deficiency is a common malocclusion frequently observed in orthodontic clinics. Miniscrew-assisted rapid palatal expansion (MARPE) not only produces greater skeletal expansion but also offers advantages such as simple miniscrew implantation without flap elevation, enhanced patient comfort, and an expanded age range and indications for palatal expansion. However, the fixed connection between the expander and the miniscrews makes the expander difficult to remove, significantly hindering its clinical application.
View Article and Find Full Text PDFChitosan-alginate microcapsules: A strategy for improving stability and antibacterial potential of bovine Lactoferrin.
Int J Biol Macromol
March 2025
Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados, Consejo Nacional de Investigaciones Científicas y Técnicas (IITEMA, CONICET), Universidad Nacional de Río Cuarto (UNRC), Río Cuarto 5800, Córdoba, Argentina. Electronic address:
Lactoferrin, a multifunctional glycoprotein with significant biological properties, presents significant potential for the prevention and treatment of infectious diseases. However, the effectiveness of oral Lactoferrin is limited by its susceptibility to degradation in harsh stomach conditions, reducing its bioavailability and therapeutic efficacy. To address this challenge, this study employs Chitosan/Alginate microparticles to enhance Lactoferrin stability and antibacterial activity.
View Article and Find Full Text PDFHigh-dose oral minoxidil for the treatment of androgenetic alopecia.
Actas Dermosifiliogr
March 2025
Servicio de Dermatología, Unidad de Tricología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, España; Unidad de Tricología y Trasplante Capilar, Clínica Grupo Pedro Jaén, Madrid, España.
Low-dose oral minoxidil (≤ 5 mg daily) has emerged as an effective off-label treatment for androgenetic alopecia, outperforming topical minoxidil in terms of adherence. However, the optimal dose has not yet been determined, and high doses may cause systemic adverse effects. This retrospective study of 57 patients evaluated the safety and efficacy profile of oral minoxidil at higher doses (> 5 mg).
View Article and Find Full Text PDFExploring alternative approaches: A case report on palmoplantar keratoderma treated with unani medicine.
Explore (NY)
March 2025
Department of Amraze Jild wa Tazeeniyat (Dermatology and Cosmetology), National Institute of Unani Medicine, Bangalore, India.
Introduction: Palmoplantar Keratoderma (PPK) is a heterogeneous group of hereditary and acquired cornification disorders defined by hyperkeratosis of the palms and soles, often resulting in significant discomfort and reduced quality of life. The clinical features include well defined yellowish hyperkeratotic plaques on palm and soles. Treatment typically relies on topical keratolytic agents, including salicylic acid, lactic acid, urea and in more severe cases, systemic therapy with oral retinoids may be required.
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