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Amoxicillin Blood Concentration in High-Dose Intravenous Discontinuous Amoxicillin: Look Beyond Numbers. Max-Amox Study.
Clin Ther
December 2024
Department of Infectious Diseases, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:
Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).
View Article and Find Full Text PDFA second look at secondary hypogammaglobulinemia.
Ann Allergy Asthma Immunol
December 2024
Division of Allergy, Immunology, Rheumatology, Rochester Regional Health, University of Rochester, Rochester, New York.
Hypogammaglobulinemia is defined as a reduced immunoglobulin level, which can be either primary due to inborn errors of immunity or acquired in the setting of poor antibody production or increased antibody loss. Secondary hypogammaglobulinemia (SHG) should be considered in patients with a history of immunosuppressive therapy, transplant, protein loss syndromes, certain autoimmune conditions, and malignancies, as it can be associated with increased infectious risk. Appropriate history and lab-based screening in these populations can identify SHG allowing treatment and close monitoring as appropriate.
View Article and Find Full Text PDFManagement of large or giant Extracranial carotid artery aneurysms: a single-center experience.
BMC Neurol
November 2024
Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, 137 south of Liyushan Road, Urumqi, 830054, Xinjiang, People's Republic of China.
Background: Extracranial carotid artery aneurysm (ECCA) is an infrequent disease with an incidence of less than 1%. However, our understanding is still incomplete, and the preferred method to treat ECAA remains unknown.
Methods: To share our initial experience with treatment options for large ECCAs.
Urethral strictures - General aspects: Definition, anatomy of the urethra and its clinical application in stenosis, epidemiology, etiology, and principles of urethral reconstruction.
Fr J Urol
November 2024
Department of Urology, La Conception Academic Hospital, Assistance publique-Hôpitaux de Marseille (AP-HM), Marseille, France.
Background: Urethral strictures are a common and persistent pathology in urology with significant clinical repercussions. Our aim is to provide an overview of the general aspects of this condition.
Methods: A comprehensive review of the literature from PubMed was conducted covering the period from 2020 to 2023.
Life-threatening complications in ophthalmic surgery: a systematic review.
Eye (Lond)
January 2025
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Article Synopsis
- * Cardiovascular events are the most common life-threatening complications, including oculocardiac reflex and iatrogenic vascular air embolism, which can lead to severe consequences like respiratory distress.
- * The review discusses potential complications, focusing on their causes, risk factors, symptoms, and management strategies, with particular attention to rare but serious infections like necrotizing fasciitis.
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