In the context of the classification of hypercalciuria in urolithiasis, the measurement of enteral calcium absorption is very important. A precise method is that of oral load with 47Ca and measurement of its activity by means of a human body counter; 47Ca activity in serum, urine and stools in simultaneously measured. To date 47 patients with chronically recidive calcium lithiasis (with between 3 and over 100 stone episodes) and an average age of 43.2 years have been examined. Calcium absorption lay between 42.7% and 90.0% of the dose, the average was 59.3% with a standard deviation of +/- 12.9. This is higher than in persons with healthy kidneys, but not significantly so. Calcium absorption is significantly lower in patients with renal insufficiency. The studies on calcium kinetics revealed turnover rates and pool sizes within the normal range.
Download full-text PDF |
Source |
---|
PLoS One
January 2025
Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok, Thailand.
Although long-term high dietary sodium consumption often aggravates hypertension and bone loss, sodium in the intestinal lumen has been known to promote absorption of nutrients and other ions, e.g., glucose and calcium.
View Article and Find Full Text PDFCurr Drug Deliv
January 2025
Department of Biopharmaceutical, Lishui University, 1 Xueyuan Road, Lishui, 323000, China.
Background: Overcoming the poor aqueous solubility of small-molecule drugs is a major challenge in developing clinical pharmaceuticals. Felodipine (FLDP), an L-type calcium calcium channel blocker, is a poorly water-soluble drug.
Objectives: The study aimed to explore the potential applications of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) stabilized amorphous dispersions for augmenting the oral delivery of poorly water-soluble drugs.
Acta Physiol (Oxf)
February 2025
Institute for Molecular Medicine, Health and Medical University Potsdam, Potsdam, Germany.
Ca and Mg are essential nutrients, and deficiency can cause serious health problems. Thus, lack of Ca and Mg can lead to osteoporosis, with incidence rising both in absolute and age-specific terms, while Mg deficiency is associated with type II diabetes. Prevention via vitamin D or estrogen is controversial, and the bioavailability of Ca and Mg from supplements is significantly lower than that from milk products.
View Article and Find Full Text PDFPlant Physiol Biochem
January 2025
Department of Applied Biosciences, Kyungpook National University, 41566, Daegu, Republic of Korea. Electronic address:
Plant growth-promoting rhizobacteria (PGPR) and biochar (BC) are recognized as effective biological agents for enhancing stress tolerance and mitigating heavy metal toxicity in crops. Therefore, this study aims to investigate the effects of the cadmium (Cd)-resistant PGPR strain Leclercia adecarboxylata HW04 (>4 mM Cd resistance) on soybean plants exposed to 300 μM Cd. HW04 was observed to possess the innate ability to synthesize indole-3-acetic acid and exopolysaccharides, which facilitated the absorption of Cd in the medium.
View Article and Find Full Text PDFTalanta
January 2025
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland. Electronic address:
An idea of using ion-exchanger salt containing optically active cations to prepare ion-selective membranes is proposed. Although the presence of an ion-exchanger in the composition of neutral ionophore based sensors is necessary, the choice of available salts for cation-selective sensors preparation, is usually limited to sodium or potassium compounds. In this work we propose application of an alternative salt, using a cation optically active both in absorption and emission mode as a mobile one.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!