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Magnusiomyces capitatus, an Unusual Cause of Invasive Fungal Infections in Neutropenic Patients: Case Reports and Outbreak Investigation.
Mycopathologia
January 2025
Department of Clinical Microbiology, St. James Hospital, Dublin, Ireland.
Magnusiomyces capitatus is an environmental fungus found in soil, water, air, plants, and dairy products which may cause opportunistic infections in patients with haematological disorders resulting in high mortality rates. This series of the first reported cases in Ireland discusses investigation of two patients with underlying haematological disorders, hospitalised in the Irish National Adult Stem Cell Transplant Unit (NASCTU), who developed line-related fungaemias with M. capitatus within a three-month period.
View Article and Find Full Text PDFSafety of Crovalimab Versus Eculizumab in Patients With Paroxysmal Nocturnal Haemoglobinuria (PNH): Pooled Results From the Phase 3 COMMODORE Studies.
Eur J Haematol
February 2025
Division of Hematology, Hospital A Beneficência Portuguesa, São Paulo, Brazil.
Objectives: To evaluate the tolerability of crovalimab versus eculizumab in C5 inhibitor (C5i)-naive and -experienced patients with PNH from COMMODORE 2, 3 and 1 (NCT04434092, NCT04654468 and NCT04432584).
Methods: Pooled safety data were assessed in the total crovalimab and eculizumab populations and by C5i-naive versus C5i-switched status in patients receiving crovalimab. Analyses include 6.
Hemolytic reaction after major and minor compatible blood transfusion for a cesarean section patient in a resource-limited area: A case report.
Int J Surg Case Rep
November 2024
Wachemo University Comprehensive and Specialized Hospital, Hosanna, Ethiopia.
Article Synopsis
- A hemolytic transfusion reaction results from immunological incompatibility between donor and recipient blood, leading to red blood cell destruction and symptoms of increased red cell death, even in rare cases of compatible transfusions.
- The case presented involves a 27-year-old pregnant woman with blood group AB positive who experienced anemia and hypotension due to antepartum hemorrhage; she underwent surgery, was monitored, and was discharged with stable lab results after three days.
- Acute hemolytic transfusion reactions are rare but serious, occurring in about 1 in 70,000 transfusions; typical symptoms may not be obvious if the patient is anesthetized, highlighting the need for careful monitoring post-transfusion
Fatal Neutropenic Enterocolitis in a Young Female After the First Round of Eculizumab for Paroxysmal Nocturnal Hemoglobinuria.
Cureus
September 2024
Internal Medicine, University of Miami at Holy Cross, Fort Lauderdale, USA.
Article Synopsis
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder causing anemia and thrombosis due to a deficiency of specific membrane proteins, which may lead to severe neutropenia and a risk of neutropenic enterocolitis (NEC).
- A case is presented of a 31-year-old woman who developed fatal NEC after receiving eculizumab treatment for PNH, experiencing symptoms like abdominal pain, fever, and worsening neutropenia.
- Despite intensive treatment efforts, she suffered from septic shock and multiple organ failures, ultimately resulting in brain death, illustrating the critical need for early detection and management in patients at high risk for NEC.
Recurrent acute myocardial and renal infarction with aplastic anaemia/paroxysmal nocturnal haemoglobinuria syndrome: a case report.
Eur Heart J Case Rep
October 2024
Department of Cardiovascular Medicine, Saiseikai Shiga Hospital, 2-4-1 Ohashi, Ritto, Shiga 520-3046, Japan.
Article Synopsis
- * A 24-year-old woman with AA presented with chest pain and was found to have a thrombus in her coronary artery, leading to a heart attack and subsequent renal infarction, prompting further examinations and diagnoses.
- * Treatment with ravulizumab, an antibody targeting complement C5, successfully managed her thrombosis and alleviated her symptoms, highlighting its effectiveness against complications linked to PNH.
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