C57BL/6J mice, after having been exposed to a free-choice condition between water and aqueous chlordiazepoxide (CDP, 25 mg/100 ml) or between water and ethanol/CDP, showed a significant trend for decreased preference for ethanol when tested 2 weeks later. Similarly, mice previously exposed to a no-choice intake of ethanol showed a significant decrease in ethanol preference when tested subsequently. A long-lasting (greater than 20 weeks) reduction in ethanol selection developed after mice were previously exposed to ethanol/CDP in a no-choice condition. This was also accompanied by a decrease in the subsequent selection of ethanol/CDP, but not CDP. The exact mechanisms for the long-lasting decrease in ethanol selection was unknown, but it was not due to the development of fluid aversion. It is suggested that the combined central effects of ethanol/CDP might be partially responsible.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0091-3057(83)90052-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Understanding the CO Reduction Selectivity toward Ethanol on Single Atom Doped Cu/CuO Catalysts: Insights from Bader Charge as a Descriptor.
J Phys Chem Lett
January 2025
Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Normal University and Strait Laboratory of Flexible Electronics (SLoFE), Fuzhou, Fujian 350117, China.
In the CO reduction reactions (CORR), the product selectivity is strongly dependent on the binding energy differences of the key intermediates. Herein, we systematically evaluated the CORR reaction pathways on single transition metal atom doped catalysts TMCu/CuO by density functional theory (DFT) methods and found that *CO is more likely to undergo C-O bond cleavage rather than be hydrogenated on TMCu/CuO (TM = Sc, Ti, V, Cr, Mn, Fe, Co), which facilitates C production with a low-energy pathway of OC-C coupling, while it prefers to be hydrogenated to form CHO on TMCu/CuO (TM = Ni, Cu). The defects of Cu in TMCu/CuO were confirmed to enhance the production of ethanol.
View Article and Find Full Text PDFOptimizing voriconazole-loaded thermoresponsive hydrogel: tools and studies.
Drug Dev Ind Pharm
January 2025
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.
Objective: The present study aims to develop and evaluate the voriconazole-loaded thermoresponsive hydrogel using tools.
Methods: Poloxamer 407 and PEG 400 were selected as the components from studies for thermoresponsive hydrogel of voriconazole. The cohesive energy density (CED) and solubility parameters (SP) were calculated using Biovia Material Studio 2022 software to predict the polymer-polymer miscibility and drug-polymer miscibility.
Effect of hydro-ethanol extract of Caesalpinia pulcherrima (L.) Sw. leaves in human and rat: In vitro approach of male contraceptive development.
JBRA Assist Reprod
January 2025
Molecular Medicine, Nutrigenomics and Public Health Research Laboratory, Department of Bio-Medical Laboratory Science and Management, Vidyasagar University, Midnapore 721 102, West Bengal, India.
Objective: The study focused the contraceptive efficacy of hydro-ethanolic (60:40) extract (HEE) of Caesalpinia pulcherrima leaves in human and rat sperm samples by in vitro study.
Methods: Six young fertile adult males were selected for semen collection. Sperm samples were collected from six adult rat also by chopping the epididymis along with the collection of testicles, epididymis, and liver.
State-of-the-art advances in homogeneous molecular catalysis for the Guerbet upgrading of bio-ethanol to fuel-grade bio-butanol.
Chem Commun (Camb)
January 2025
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati - 781039, Assam, India.
The upgrading of ethanol to -butanol marks a major breakthrough in the field of biofuel technology, offering the advantages of compatibility with existing infrastructure while simultaneously offering potential benefits in terms of transport efficiency and energy density. With its lower vapour pressure and reduced corrosiveness compared to ethanol, -butanol is easier not only to manage but also to transport, eliminating the need for costly infrastructure changes. This leads to improved fuel efficiency and reduced fuel consumption.
View Article and Find Full Text PDFEfficient in-droplet cell culture and cytomechanics measurement for assessment of human cellular responses to alcohol.
Anal Chim Acta
February 2025
Robotics and Microsystems Center, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, 215000, China. Electronic address:
Background: Excessive alcohol consumption poses a significant threat to human health, leading to cellular dehydration, degeneration, and necrosis. Alcohol-induced cellular damage is closely linked to alterations in cellular mechanical properties. However, characterizing these changes following alcohol-related injury remains challenging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!