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Applicability of tooth cementum thickness as an age marker: systematic review and meta-analysis.
Int J Legal Med
January 2025
Department of Stomatology, Public Health and Forensic Odontology, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
The age estimation by tooth cementum thickness is a method that has been discussed regarding its applicability. The aim of this study was to conduct a systematic review on the use of tooth cementum thickness as a biomarker for age estimation in adults, as well as a meta-analysis to assess the method's reliability. The search was conducted on Embase, LILACS, PubMed/MEDLINE, SciELO, Scopus, and Web of Science databases.
View Article and Find Full Text PDFMetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets.
Front Neurosci
January 2025
Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, United States.
Introduction: In the rapidly advancing field of 'omics research, there is an increasing demand for sophisticated bioinformatic tools to enable efficient and consistent data analysis. As biological datasets, particularly metabolomics, become larger and more complex, innovative strategies are essential for deciphering the intricate molecular and cellular networks.
Methods: We introduce a pioneering analytical approach that combines Principal Component Analysis (PCA) with Graphical Lasso (GLASSO).
Mouse-derived Synaptosomes Trypsin Cleavage Assay to Characterize Synaptic Protein Sub-localization.
Bio Protoc
January 2025
Department of Structural Interactomics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Neurons communicate through neurotransmission at highly specialized junctions called synapses. Each neuron forms numerous synaptic connections, consisting of presynaptic and postsynaptic terminals. Upon the arrival of an action potential, neurotransmitters are released from the presynaptic site and diffuse across the synaptic cleft to bind specialized receptors at the postsynaptic terminal.
View Article and Find Full Text PDFMouse Model of Lipopolysaccharide (LPS)-Induced Pulpitis.
Bio Protoc
January 2025
Department of Stomatology, Peking Union Medical College Hospital, Beijing, China.
Pulpitis is an important and prevalent disease within the oral cavity. Thus, animal models are necessary tools for basic research focused on pulpitis. Researchers worldwide often use dogs and miniature pigs to construct animal models of pulpitis.
View Article and Find Full Text PDFInvestigation of compounds as ERK5 inhibitor related to breast cancer via molecular docking and dynamic simulation.
In Silico Pharmacol
January 2025
Teady Bioscience Research Laboratory, Ilara Mokin, Ondo State Nigeria.
Unlabelled: Breast cancer remains a global health challenge, with rising cases predicted in the coming decades. The complexity of breast cancer treatment arises from its complex nature, often involving multiple therapeutic strategies. One promising approach is targeting the ERK5 pathway, a key regulator in cancer cell proliferation and survival.
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