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Neonatal acute liver failure cases with echovirus 11 infections, Japan, August to November 2024.
Euro Surveill
January 2025
President's office, National Center for Child Health and Development, Tokyo, Japan.
In 2022-23, several European countries reported paediatric acute liver failure (ALF) with enterovirus infection. In August-November 2024, three neonatal cases of ALF with echovirus 11 (E11) were reported in Tokyo, Japan. All neonates developed irreversible multiple-organ failure and died.
View Article and Find Full Text PDFRecent Molecular Epidemiology of Echovirus 11 Throughout North and West Africa Resulted in the First Identification of a Recombinant Strain from an Acute Flaccid Paralysis Case in West Africa.
Viruses
November 2024
Virology Department, Institut Pasteur de Dakar, 36 Avenue Pasteur, Dakar 220, Senegal.
Article Synopsis
- Echovirus 11 is causing increasing cases of neonatal sepsis in Europe and limited reports in West Africa, highlighting a significant public health issue.
- A study analyzed 23 E11 strains from West Africa using high-throughput sequencing, marking the first molecular characterization of the virus in the region and revealing a new recombinant strain.
- The research indicates that E11 has evolved into four distinct clades since the 1970s, with instances of the virus spreading from West Africa to Europe, underscoring the need for enhanced surveillance of enteroviruses in Africa.
Icariin ameliorates Coxsackievirus B3-induced viral myocarditis by modulating the S100 calcium binding protein A6/β-catenin/c-Myc signaling pathway.
Phytomedicine
December 2024
The First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. Electronic address:
Background: Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis and is currently lacking specific pharmacological treatments, highlighting the critical need for therapeutic development. Icariin (ICA), a prenylated flavonol glycoside, was previously found to exhibit several pharmacological effects, but its potential to combat CVB3 remains uninvestigated.
Purpose: This study aimed to elucidate the anti-CVB3 efficacy of ICA and elucidate its molecular mechanisms.
Enhanced echovirus 11 genomic surveillance in neonatal infections in Spain following a European alert reveals new recombinant forms linked to severe cases, 2019 to 2023.
Euro Surveill
October 2024
The members of the study group are listed under Collaborators.
Article Synopsis
- In 2023, Europe raised concerns about rising severe neonatal infections due to a new lineage of echovirus 11 (E11), prompting an analysis of E11 cases in Spain from 2019 to 2023.
- Out of 1,288 samples, 103 were found to be E11-positive, but the detection rates and severity of infections among neonates did not significantly change after the new lineage appeared in June 2022.
- The findings suggest that the new lineage 1 is not responsible for increased neonatal infections, but the discovery of novel E11 recombinants linked to severe cases highlights the need for better monitoring and surveillance.
Parkin plays a crucial role in acute viral myocarditis by regulating mitophagy activity.
Theranostics
September 2024
From the Department of Cardiology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Parkin (an E3 ubiquitin protein ligase) is an important regulator of mitophagy. However, the role of Parkin in viral myocarditis (VMC) remains unclear. Coxsackievirus B3 (CVB3) infection was induced in mice to create VMC.
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