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Isoleucine at position 137 of Hemagglutinin acts as a Mammalian adaptation marker of H9N2 Avian influenza virus.
Emerg Microbes Infect
January 2025
Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Liaoning Panjin Wetland Ecosystem National Observation and Research Station, Shenyang Agricultural University, Shenyang, People's Republic of China.
The H9N2 subtype of avian influenza virus (AIV) is widely distributed among poultry and wild birds and is also a threat to humans. During AIV active surveillance in Liaoning province from 2015 to 2016, we identified ten H9N2 strains exhibiting different lethality to chick embryos. Two representative strains, A/chicken/China/LN07/2016 (CKLN/07) and A/chicken/China/LN17/2016 (CKLN/17), with similar genomic background but different chick embryo lethality, were chosen to evaluate the molecular basis for this difference.
View Article and Find Full Text PDFHeptamethine cyanine-based polymeric nanoparticles for photothermal therapy in HCT116 human colon cancer model.
Sci Rep
January 2025
School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.
In this work, we synthesize a quinoline-based heptamethine cyanine, QuCy7, with sulfonate groups to enhance water solubility. This dye demonstrates exceptional near-infrared absorption beyond 750 nm, accompanied by photothermal properties but low photostability. Encapsulating QyCy7 with polyethylene glycol to form nanopolymer, QuCy7@mPEG NPs, addresses the issue of its photoinstability.
View Article and Find Full Text PDFRecombinant avian metapneumovirus subtype C expressing HA protein of H9N2 avian influenza virus are stable and induce protection.
Front Microbiol
December 2024
Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
To prevent H9N2 avian influenza virus (AIV) and Avian metapneumonovirus/C (aMPV/C) infections, we constructed recombinant aMPV/C viruses expressing the HA protein of H9N2 AIV. In addition, EGFP was inserted into the intermediate non-coding region of P-M protein in the aMPV/C genome using a reverse genetic system. The conditions for rescuing the recombinant virus were enhanced followed by insertion of the H9N2 AIV HA gene into the same location in the aMPV/C.
View Article and Find Full Text PDFEnhancing broiler growth and carcass quality: impact of diets enriched with Moringa oleifera leaf powder conjugated with zinc nanoparticles.
Poult Sci
November 2024
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
This study evaluated the effects of Moringa oleifera leaf powder extract stabilized with zinc nanoparticles (ZnNPs-MLPE) as a natural growth promoter in broiler diets. Randomly assigned 264 one-day-old Ross 308 chicks to four different feeding treatments, with each group being subdivided into six replicates, each comprising 11 unsexed chicks. The control group was fed a basic diet without additives, while the experimental groups were supplemented with 1.
View Article and Find Full Text PDFThe efficacy of Artichoke leaf extract conjugated with organic zinc nanoparticles on growth, carcass traits and blood biochemical parameters of broilers.
Poult Sci
November 2024
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
This study aimed to discover how using nano artichoke leaf extract Stabilized with zinc Nanoparticles (ZnO-Nano-ALPE) as an alternative to antibiotics and an antioxidant in broiler feed affected their growth, meat quality, and blood. In a completely randomized design experiment, 210 1-day-old chicks (Arbor Acres) were assigned to three trial groups. Each group was subdivided into seven replicates, each with ten unsexed chicks.
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