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Dual-Stage Cross-Flow Filtration: Integrated Capture and Purification of Virus-Like Particles.
Biotechnol Bioeng
December 2024
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Virus-like particles (VLPs) are a versatile technology for the targeted delivery of genetic material through packaging and potential surface modifications for directed delivery or immunological issues. Although VLP production is relatively simple as they can be recombinantly produced using microorganisms such as Escherichia coli, their current downstream processing often relies on individually developed purification strategies. Integrating size-selective separation techniques may allow standardized platform processing across VLP purification.
View Article and Find Full Text PDFCRH-YOLO for precise and efficient detection of gastrointestinal polyps.
Sci Rep
December 2024
Faculty of Computer and Software Engineering, Huaiyin Institute of Technology, Huaian, 223003, China.
Gastrointestinal polyps are early indicators of many significant diseases within the digestive system, and timely detection of these polyps is crucial for preventing them. Although clinical gastrointestinal endoscopy and interventions help reduce the risk of malignancy, most current methods fail to adequately address the uncertainties and scale issues associated with the presence of polyps, posing a threat to patients' health. Therefore, this paper proposes a novel single-stage method for polyp detection.
View Article and Find Full Text PDFImpact of Pre-pectoral Implant Placement and Radiation Modalities (Protons/Photons) in Mastectomy Patients undergoing Immediate Direct-to-Implant Breast Reconstruction.
Int J Radiat Oncol Biol Phys
November 2024
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School. Electronic address:
Background: For breast cancer patients receiving mastectomy with direct-to-implant (DTI) immediate breast reconstruction, placing the implant in the pre-pectoral or subpectoral plane remains debatable; especially in settings of postmastectomy radiotherapy (PMRT).
Materials/methods: We reviewed 3,039 patients who underwent mastectomy and reconstruction at our institution between 2005 and 2020. Patients receiving DTI with and without PMRT were included.
A single step transvaginal surgery in managing vesicovaginal fistula with grade III cystocele in post hysterectomy patient: A case report and literature review.
Int J Surg Case Rep
November 2024
Department of Urology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Teaching Hospital, Surabaya, Indonesia. Electronic address:
Article Synopsis
- Vesicovaginal fistula (VVF) is a serious complication that can arise after surgeries like hysterectomy, often leading to other issues such as pelvic organ prolapse and a decrease in quality of life for women.
- A case study of a 53-year-old woman with VVF and cystocele demonstrates successful treatment through a single-step transvaginal surgery, which improved her urinary incontinence and overall wellbeing.
- VVF and cystocele post-hysterectomy are uncommon but can significantly affect women's health; this case highlights that one-time surgical intervention can be an effective solution, minimizing the need for multiple treatments.
Perioperative Outcomes and Feasibility of Single-Stage Laparoscopic Common Bile Duct Exploration (LCBDE) and Cholecystectomy With Internal Endo-Biliary Drainage for Management of Concomitant Cholelithiasis With Choledocholithiasis: A Report From a Tertiary Care Hospital.
Asian J Endosc Surg
November 2024
Department of General Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.
Introduction: Managing choledocholithiasis alongside cholelithiasis has seen significant evolution, presenting options such as single-stage cholecystectomy with common bile duct (CBD) exploration, or a two-stage procedure involving endoscopic retrograde cholangiopancreatography (ERCP) performed before or after cholecystectomy. Evidence from Western settings may not fully capture the unique disease burden and demographic characteristics prevalent in developing countries. Laparoscopic common bile duct exploration (LCBDE) is more commonly performed in the Indian subcontinent compared to Western centers due to limited access to advanced procedures and specialized instrumentation for complex ERCP cases.
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