Response to sustained (three-minute) handgrip at one-third maximum contraction was studied in 75 subjects with essential hypertension. The patients responded with an increase in heart rate, systolic and diastolic blood pressure, and double product. Chronic atenolol therapy (100 mg/day in a single administration) decreased the values of these measurements at rest and during exercise. The treatment did not prevent or attenuate the rise in heart rate with grip, but it partially inhibited the pressor response to handgrip. Chronic atenolol therapy may reduce the risk of vascular disease by decreasing blood pressure and its response to isometric exercise. Additionally, chronic beta-adrenergic blockade with decreased heart rate, double product, and, most likely, myocardial oxygen consumption is probably a further cardioprotective factor.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Stress and obesity signaling converge on CREB phosphorylation to promote pancreatic cancer.
Mol Cancer Res
December 2024
University of California, Los Angeles, Los Angeles, CA, United States.
One of the deadliest types of cancer is pancreatic ductal adenocarcinoma (PDAC). Chronic stress and obesity are recognized as risk factors for PDAC. We hypothesized that the combination of stress and obesity strongly promotes pancreatic cancer development and growth.
View Article and Find Full Text PDFBeta-adrenergic blockade via atenolol negatively affects body and heart mass and renal morphology in the developing chicken (Gallus Gallus Domesticus).
Comp Biochem Physiol C Toxicol Pharmacol
November 2024
Developmental Integrative Biology Group, The University of North Texas, 1155 Union Circle, Denton, TX 76203, USA. Electronic address:
Atenolol is a widely prescribed β-cardioselective blocker. We studied atenolol effects on cardiac and renal development in day 18 (D18) chicken embryos. Embryos were dosed with atenolol (3 μg atenolol/g estimated embryo mass) for three days during one of the mesonephric kidney stage (D7-D9), mesonephric-metanephric stage (D11-D13), or metanephric stage (D15-D17), and then sampled on D18.
View Article and Find Full Text PDFTemporal variability and ecological risks of pharmaceuticals and cocaine during the Christmas and New Year holidays in a beach area of North Coast of São Paulo, Brazil.
Mar Environ Res
November 2024
Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Avenida General Norton de Matos S/N, 4450-208, Matosinhos, Portugal; Escola das Ciências da Vida e do Ambiente (ECVA), Universidade de Trás-os-Montes e Alto Douro (UTAD), 5000-801, Vila Real, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.
Article Synopsis
- The study analyzed the presence and potential ecological risks of nine pharmaceuticals in the Juquehy River, which leads to a popular beach in São Paulo, Brazil.
- Findings showed a significant increase in pharmaceutical concentrations during the busy holiday season compared to baseline levels, with caffeine and losartan being the most prevalent.
- The ecological risk assessment indicated moderate environmental concerns for aquatic life, particularly from caffeine and losartan, highlighting risks to algae, crustaceans, and fish due to both acute and chronic exposure.
β-Adrenoceptor blockade can augment the torsadogenic action of risperidone.
J Pharmacol Sci
October 2024
Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. Electronic address:
Article Synopsis
- Risperidone is a second-generation antipsychotic used for schizophrenia and bipolar disorder, but it has a conditional risk for causing torsade de pointes (TdP), a serious heart arrhythmia.
- Research on dogs with chronic atrioventricular block showed that while risperidone alone did not induce TdP, combining it with the β-adrenoceptor blocker atenolol increased the risk significantly.
- The study suggests that using β-adrenoceptor blockers with risperidone can lower the heart's repolarization reserves, which raises the potential for TdP, highlighting the need for caution in patients with heart-related issues.
A Reversible Etiology of Progressive Motor Decline in a Previously Healthy Child.
Pediatrics
September 2024
Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, California.
Article Synopsis
- A 10-year-old boy experienced progressive muscle weakness, atrophy, and weight loss, along with symptoms like tachycardia, tremor, and learning issues.
- Electromyography showed chronic myopathic changes, and lab tests indicated undetectable thyroid stimulating hormone, high thyroid peroxidase antibodies, and thyroid stimulating immunoglobulins.
- After treatment with atenolol and methimazole, the boy's strength and cognitive abilities improved, emphasizing the need to consider reversible causes for neurologic symptoms in children.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!