Analysis of 18 autopsy observations of status thymicolymphaticus (STL) in patients aged from 14 to 44 years is presented. The clinical diagnosis of STL in adults was shown to be unsatisfactory because physicians are not properly acquainted with its clinical manifestations. The latter are in some cases conditioned by predominant involvement of the endocrine system, in others by incompetence of immunogenesis. Fatal complications developing in some cases of STL are associated with congenital abnormalities in the cardiovascular system. Morphological signs of STL include hyperplasia of the thymus and lymphoid tissue in combination with adrenal hypoplasia and, in most cases, with cardiovascular abnormalities. This analysis suggests that STL is a congenital syndrome of immunoendocrine insufficiency combined in the great majority of cases with other malformations.
Download full-text PDF |
Source |
---|
Forensic Sci Med Pathol
May 2024
University Department of Internal Medicine, Unit of Cardiovascular Disease Clinical Hospital Sveti Duh, Zagreb, School of Medicine Catholic University of Croatia, Zagreb, Croatia.
Rom J Morphol Embryol
December 2018
Department of Morphological Sciences, University of Medicine and Pharmacy of Craiova, Romania;
Sudden infant death syndrome (SIDS) is the sudden, unexpected death of an infant less than one year of age that remains unexplained after a full investigation. SIDS is the most frequent cause of death of infants between two weeks and one year of age, explaining 35% to 55% of all deaths in this age group. We report a newborn male who died soon after birth.
View Article and Find Full Text PDFThe history of medicine includes many errors. Some persisted for decades and caused great harm. Several are highlighted in this article, including the mythical thymic diseases: thymic asthma and status thymicolymphaticus.
View Article and Find Full Text PDFAcad Forensic Pathol
June 2017
Calgary Laboratory Services - Pathology & Laboratory Medicine.
Sudden infant death syndrome (SIDS) became a named entity in 1969 and the term has been used to certify sudden unexpected infant deaths meeting certain demographic, epidemiologic, and pathologic criteria. Since it is a diagnosis of exclusion, there is inherent imprecision, and this has led the National Association of Medical Examiners to recommend that these deaths now be classified as "undetermined." This historical review article briefly analyzes anecdotal instances of SIDS described centuries ago as overlying, smothering, infanticide, and suffocation by bedclothes followed by a more detailed review of "thymic" causes (i.
View Article and Find Full Text PDFLeg Med (Tokyo)
November 2014
Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki 569-8686, Japan. Electronic address:
Cardiac ryanodine receptor gene (RyR2) mutations sometimes result in sudden cardiac death due to fatal arrhythmias. N-terminal R420W mutation of RyR2 is known to show similar phenotypes to arrhythmogenic right ventricular cardiomyopathy and to cause juvenile sudden death. We previously reported two sudden death cases with the same R420W mutation.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.