The problem of efficacy prediction for psychopharmacotherapy of depressions is of considerable interest and urgency in view of frequently occurring resistance to antidepressants. The purpose of the present study was to study the feasibility of predicting the effectiveness of depression therapy in manic-depressive psychosis (MDP), based on the cross-sectional analysis of the patient's history (the clinical picture of the patient's condition prior to therapy) with the help of multivariate statistics. Eighty-two patients suffering from MDP with a variety of depressive states were examined. In addition to traditional descriptions, the clinical findings were documented by employing a system of standard evaluation scales. The data obtained were processed using the technique of multiple stepwise discriminant analysis. The latter resulted in the derivation of a mathematical prognostic formula allowing the prediction of tricyclic antidepressants efficacy.
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