[Lipid metabolism and free-radical oxidation in children with glomerulonephitis incorporating plant fats into their diet].

A study was made of the effect of vegetable fats on lipid metabolism and free radical oxidation, phospholipase activity and antioxidant content in 43 children suffering from chronic glomerulonephritis. After intake of a vegetative fat in a dose of 2 g/kg bw for 7 days the sick children demonstrated a significant rise in the level of total lipids in red cells and in their excretion with urine. This was in a good agreement with an increase in phospholipase activity in blood and diminution of lipid peroxides in red cell membranes. The reaction of antioxidant enzymes metabolizing hydrogen peroxide was different. Catalase activity in urine was elevated, whereas urine peroxidase activity was decreased. All these changes gave rise to a decrease in the pool of peroxide radicals which correlated with the time course of hydroperoxides. The biochemical data indicate that lipids contained by vegetative fats may be regarded as treatment-and-dietetic factor in multiple modality therapy of children with renal diseases.