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Expression of Major Basic Protein and Endothelial Adhesion Molecules in Chronically Inflamed Mucosa of the Ethmoid Labyrinth.
Immun Inflamm Dis
December 2024
Department of Otorhinolaryngology, Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia.
Background/objectives: Tissue remodeling, including dense eosinophil infiltration, is essential for forming inflammatory nasal polyps (NPs) and the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Toxic eosinophil major basic protein (MBP) damages the sinus mucosa epithelium and lamina propria, which initiates reparative processes leading to tissue remodeling. MBP specifically binds to BMK-13 antibodies allowing immunohistochemical (IHC) tissue staining for eosinophils.
View Article and Find Full Text PDFMETTL3-dependent mA modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway.
Cell Death Dis
March 2024
Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging evidence underscores the importance of mA modifications in various bioprocesses such as stem cell differentiation, tissue development, and tumorigenesis. Here, in vivo, experiments with zebrafish models revealed that mettl3-knockdown embryos at 144 h postfertilization exhibited aberrant craniofacial features, including altered mouth opening, jaw dimensions, ethmoid plate, tooth formation and hypoactive behavior.
View Article and Find Full Text PDFFrontal sinus approach in complicated chronic rhinosinusitis with nasal polyps: Our experience.
Caspian J Intern Med
January 2023
North-Western State Medical University named after I.I. Mechnikov, Saint-Petersberg, Russia.
Background: Hyperostosis is a common consequence of chronic rhinosinusitis with nasal polyps (CRSwNP) and other chronic rhinosinusitis, affecting mainly structures of the ethmoid labyrinth, frontal and maxillary sinuses. These neo-bones are found in advanced stages of rhinosinusitis causes exacerbation because of ostia outflow blockage. Frequent relapses of the disease due to hyperostosis restenosis, represent a problem in the treatment of chronic frontal sinusitis.
View Article and Find Full Text PDFDomestic cat nose functions as a highly efficient coiled parallel gas chromatograph.
PLoS Comput Biol
June 2023
Department of Otolaryngology-Head & Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America.
The peripheral structures of mammalian sensory organs often serve to support their functionality, such as alignment of hair cells to the mechanical properties of the inner ear. Here, we examined the structure-function relationship for mammalian olfaction by creating an anatomically accurate computational nasal model for the domestic cat (Felis catus) based on high resolution microCT and sequential histological sections. Our results showed a distinct separation of respiratory and olfactory flow regimes, featuring a high-speed dorsal medial stream that increases odor delivery speed and efficiency to the ethmoid olfactory region without compromising the filtration and conditioning purpose of the nose.
View Article and Find Full Text PDFPrevalence of Oestrus ovis in small ruminants from the eastern Iberian Peninsula. A long-term study.
Med Vet Entomol
June 2023
Parasitology, Department Animal Health, Faculty of Veterinary Medicine, Campus de Excelencia Internacional Regional 'Campus Mare Nostrum', Universidad de Murcia, Murcia, Spain.
Article Synopsis
- - Oestrus ovis is a parasite causing myiasis in sheep and goats, particularly in the Mediterranean, with a significant prevalence of 56.3% identified in a study of 3476 animals from 2009 to 2019.
- - The prevalence was higher in sheep (61.2%) compared to goats (43%), and peaked in 2018, with autumn being the most infested season for sheep and winter for goats; temperature, rather than rainfall, correlated with prevalence rates.
- - Most larvae were found in specific anatomical regions, with an average intensity of 12.8 larvae per animal, showing a notable increase in recent years linked to rising temperatures.
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