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Down syndrome with cryptorchidism and retroperitoneal mixed germ cell tumour in an adult patient: a case report and literature review.
World J Surg Oncol
January 2025
Department of Colorectal Surgery, Dingli Clinical College, Wenzhou Medical University (Wenzhou Central Hospital), 252 Baili East Road, Wenzhou, Zhejiang Province, 32500, China.
Background: An association between testicular cancer and Down syndrome has been reported by several studies. Down syndrome with cryptorchidism and retroperitoneal mixed germ cell tumours is rare, and yolk sac tumours are often considered secondary components of mixed germ cell tumours. Herein, we present a rare case of retroperitoneal mixed germ cell tumour with cryptorchidism accompanied by yolk sac tumour and seminoma in a patient with Down syndrome, along with its imaging features.
View Article and Find Full Text PDFEpithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns.
Dev Biol
January 2025
Institute for Stem Cell Science and Regenerative Medicine (iBRIC-inStem), GKVK-Post, Bellary Road, Bengaluru, Karnataka 560065, India. Electronic address:
Article Synopsis
- The lower urinary tract, consisting of the bladder and urethra, develops from the cloaca, with the bladder forming from the urogenital sinus and the urethra extending into the genital tubercle.
- Engineering a fully functional bladder lining is challenging, and the urethral epithelium's immune roles are under-researched, highlighting the need for a better understanding of the epithelial and mesenchymal interactions that drive development.
- This study identified specific genes involved in bladder and urethra development in mice, revealing differences in gene expression patterns related to sex and offering insights for future regenerative therapies.
Ovarian yolk sac tumors (OYSTs), also known as endodermal sinus tumors, are rare and highly malignant germ cell tumors, accounting for approximately 1% of all ovarian cancers. They predominantly affect children and young adults, with a rapid growth rate and early metastasis, making early diagnosis and treatment crucial. This report presents the case of a 6-year-old female from a low-resource setting who initially presented with symptoms suggestive of acute appendicitis, including abdominal pain, fever, and vomiting.
View Article and Find Full Text PDF[Atypical polypoid adenomyoma evolves into endometrial endometrioid carcinoma with retro-differentiation of yolk sac tumor: report of a case].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Peking University Third Hospital, Beijing100191, China School of Basic Medical Sciences, Peking University Health Science Center, Beijing100191, China.
Diagnostic features of pediatric testicular yolk sac tumors: a 13-year retrospective analysis.
World J Surg Oncol
December 2024
Department of Radiology, Shenzhen Children's Hospital, 7019 Yitian Road, Futian District, Shenzhen, 518038, China.
Background: Testicular yolk sac tumor (YST) is a rare neoplasm with limited practical guidance for preoperative diagnostic assessment. This study aims to conduct a retrospective analysis of the value of clinical profiles and MRI parameters in accurately diagnosing pediatric testicular YST while exploring characteristic indicators for these patients.
Methods: This retrospective study analyzed eighty patients with a testicular mass who underwent surgical treatment and preoperative MRI.
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