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With regard to the permanent increase of perioperative irradiations in case of colorectal tumors, the possible influence of irradiation on the healing of anastomoses has been investigated. 230 rats were submitted to an irradiation of the rectosigmoidal region corresponding to the therapeutic method employed in human patients (focal dose of 50 Gy, in fractions of 4 x 2 Gy per week, interval of three weeks without irradiation). Rectosigmoidal anastomoses were performed one day, four weeks, eight weeks, and four months after the irradiation. The increase of connective tissue which is decisive for the stability of the anastomosis and which can be additionally induced by irradiation, was determined 3, 7, 14 and 21 days after the operation by identification of the hydroxyproline concentration within the anastomotic region. A comparison with nonirradiated animals shows that irradiation induces an additional formation of new connective tissue which becomes more intensive as the time interval since the finishing of irradiation is longer.
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