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Structural alterations of the insula in depression patients - A 7-Tesla-MRI study.
Neuroimage Clin
December 2022
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Germany; JARA-BRAIN, 52074 Aachen, Germany. Electronic address:
Article Synopsis
- The insular cortex is linked to various psychiatric disorders, particularly major depressive disease (MDD), due to its involvement in a connected network called "rich club."
- The study used advanced imaging techniques (7T-MRI) to analyze brain structure in 33 MDD patients and 31 healthy controls, focusing on insular subfields and measuring depression severity using specific tests.
- Results showed significant differences in the insula between groups, with the gray matter volume changes and correlations between cortical thickness and depression severity highlighting the insula's importance in MDD development.
Comprehensive Psychopathological Assessment Based on the Association for Methodology and Documentation in Psychiatry (AMDP) System: Development, Methodological Foundation, Application in Clinical Routine, and Research.
Front Psychiatry
April 2017
Department of Psychiatry, Psychotherapy and Psychosomatics, Klinikum Emden, Emden, Germany.
The documentation of psychopathology is core to the clinical practice of the psychiatrist and clinical psychologist. However, both in initial as well as further training and specialization in their fields, this particular aspect of their work receives scanty attention only. Yet, for the past 50 years, the Association for Methodology and Documentation in Psychiatry (AMDP) System has been in existence and available as a tool to serve precisely the purpose of offering a systematic introduction to the terminology and documentation of psychopathology.
View Article and Find Full Text PDFPsychopathological and demographic characteristics of hallucinating patients with schizophrenia and schizoaffective disorder: an analysis based on AMDP data.
Eur Arch Psychiatry Clin Neurosci
June 2017
Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Hallucinations are at the core of the diagnosis of schizophrenia and schizoaffective disorders, and many neuroscience studies focus on hallucinations. However, there is a lack of data on prevalence, subtyping, and clinical correlates of hallucinations as well as on the comparison of hallucinating schizophrenia versus hallucinating schizoaffective patients. Analysis of all psychopathology evaluations is based on the AMDP scale in a German psychiatric university hospital between 2007 and 2013 regarding patients with schizophrenia or schizoaffective disorder (diagnosed according to ICD-10).
View Article and Find Full Text PDFSequence-Based Screening for Rare Enzymes: New Insights into the World of AMDases Reveal a Conserved Motif and 58 Novel Enzymes Clustering in Eight Distinct Families.
Front Microbiol
September 2016
Department of Microbiology and Biotechnology, Biocenter Klein Flottbek, University of Hamburg Hamburg, Germany.
Arylmalonate Decarboxylases (AMDases, EC 4.1.1.
View Article and Find Full Text PDFExploring the structure of psychopathological symptoms: a re-analysis of AMDP data by robust nonmetric multidimensional scaling.
Eur Arch Psychiatry Clin Neurosci
April 2012
Institute of Psychology, Applied Cognitive Psychology, University of Zurich, Switzerland.
This paper investigates the structure of psychopathological symptoms. Based on AMDP symptom profiles, a symptom space was calculated by robust nonmetric multidimensional scaling (NMDS) and the symptom structures of a sample dating from 1980 and a sample from 2002/2003 were compared. The method of NMDS presented in this study allows results from other studies to be confirmed and complemented.
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