The authors present the results of a retrospective analysis of the clinical peculiarities of a course of Hodgkin's disease (HD) as compared to the results of histological examination of lymph node biopsies taken for diagnostic purposes and operative material from 235 patients after exploratory laparotomy with splenectomy. It was shown that rapid transformation (from the onset of disease) of the HD histological variant of the type of "lymphoid prevalence", "nodular sclerosis" or "mixed cellular" into the "lymphoid depletion" variant attests to high rates of the evolution of a tumor process and makes it possible to recognize the subacute nature of a course of disease before treatment. The above phenomenon points to poor prognosis and should be considered in the choice of therapeutic tactics.
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