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Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer.
Curr Issues Mol Biol
December 2024
Department of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, Russia.
Adrenocortical cancer (ACC) is a rare malignant neoplasm originating from the adrenal cortex, presenting limited therapeutic options. An avenue for improving therapeutic efficacy may involve a deeper understanding of the role of adrenocortical stem/progenitor cells in the pathogenesis of this disease. Although existing data suggest stem/progenitor characteristics in certain cell populations within ACC, the challenge remains to identify adrenocortical stem cell markers directly involved in its carcinogenesis.
View Article and Find Full Text PDFTrichoscopic and Clinico-Morphological Evaluation of Tinea Capitis.
Indian Dermatol Online J
April 2024
Department of Dermatology, R.N.T. Medical College, Udaipur, Rajasthan, India.
Article Synopsis
- Tinea capitis (TC) is a prevalent fungal scalp infection mainly affecting children, and trichoscopy offers a noninvasive method for detailed hair examination.
- This study analyzed 140 TC cases over a year, revealing a prevalence rate of 2.69 per thousand and identifying gray patch as the most common variant, with specific trichoscopic features like comma and corkscrew hairs.
- The findings indicate that trichoscopy is effective for quick diagnosis, guiding treatment options, and monitoring treatment success in patients with TC.
The caspase-8 and procaspase-3 expression in gastric cancer and non-cancer mucosa in relation to clinico-morphological factors and some apoptosis-associated proteins.
Adv Med Sci
March 2023
Department of Human and Medical Genetics, Vilnius University, Vilnius, Lithuania.
Purpose: The aim of the study was to assess the expression of caspase-8 and procaspase-3 proteins in gastric cancer (GC) cells and non-cancerous mucosa in relation to clinical and morphological characteristics of the tumor, postoperative survival as well as other apoptosis-related proteins.
Materials And Methods: The study included 91 GC patients. Expression of the proteins was assessed using immunohistochemical method.
Recent update on the heterogeneity of the Alzheimer's disease spectrum.
J Neural Transm (Vienna)
January 2022
Institute of Clinical Neurobiology, Alberichgasse 5/13, 1150, Vienna, Austria.
Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed proteinopathy (β-amyloid, tau and other proteins). Classically defined as a clinicopathological entity, AD is a heterogeneous, multifactorial disorder with various pathobiological subtypes showing different forms of cognitive presentation, currently referred to as the Alzheimer spectrum or continuum. Its morphological hallmarks are extracellular β-amyloid (amyloid plaques) and intraneuronal tau aggregates forming neurofibrillary tangles and neurites, vascular amyloid deposits (cerebral amyloid angiopathy), synapse and neuronal loss as well as neuroinflammation and reactive astrogliosis, leading to cerebral atrophy and progressive mental/cognitive impairment (dementia).
View Article and Find Full Text PDFIn 142 patients, operated on for resectable gastric cancer, a dependence of the survival indices from clinico-morphological characteristics of tumoral process and peculiarities of surgical interventions was studied. Efficacy of a lymph node dissection (LND) on a D1 -D2 level was investigated. There was established, that regional lymph nodes affection in gastric carcinoma causes deterioration of indices of general and disease-free survival.
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