A mathematical description of the dose-response curve of heparin to the activated coagulation time is applied retrospectively to 20 patients treated with continuous heparin infusion. The adjusted heparin dose was compared with a calculated prediction using the theoretical mathematical model. The main actual dose was 28 U/kg/h, and the mean predicted dose was 25.8 U/kg/h. The correlation coefficient was 0.862 (p3 0.05). These data are used to develop a dosing adjustment chart. Special considerations prior to using the calculation or dosing adjustment chart are discussed. The use of this model may allow the clinician to determine more rapidly a therapeutic heparin dosage than previous empiric approaches.
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- This study compares heparin and 0.9% sodium chloride for locking peripherally inserted central catheters (PICCs) in blood cancer patients.
- Participants were randomly assigned to either locking method for up to 7 days, with no significant difference in PICC patency between the two.
- Heparin led to more side effects, higher costs, and increased nursing time, suggesting that 0.9% sodium chloride is a safer and more cost-effective option for maintenance.
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