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Histological Features of Delayed Foreign Body Granuloma With Epithelioid Histiocyte Aggregation and Eosinophilic Reaction due to Hyaluronic Acid Injection.
Case Rep Dent
December 2024
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.
Dermal fillers such as hyaluronic acid (HA) have been widely used in recent years as a less surgically invasive cosmetic treatment. Although delayed foreign body granuloma may occur as a rare adverse reaction after the procedure, detailed histological reports are still limited. When occurring on the buccal mucosa of the oral cavity, the histopathology may resemble some lesions of minor salivary gland origin due to the material properties of HA.
View Article and Find Full Text PDF3D-Q-FISH/Telomere/TRF2 Nanotechnology Identifies a Progressively Disturbed Telomere/Shelterin/Lamin AC Complex as the Common Pathogenic, Molecular/Spatial Denominator of Classical Hodgkin Lymphoma.
Cells
October 2024
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
The bi- or multinucleated Reed-Sternberg cell (RS) is the diagnostic cornerstone of Epstein-Barr Virus (EBV)-positive and EBV-negative classical Hodgkin lymphoma (cHL). cHL is a germinal center (GC)-derived B-cell disease. Hodgkin cells (H) are the mononuclear precursors of RS.
View Article and Find Full Text PDFUndifferentiated Pleomorphic Sarcoma with Reactive Eccrine Syringofibroadenoma: A Case Report.
Dermatopathology (Basel)
October 2024
Southern Regional Hospital of Tropical Dermatology-Trang Province, Department of Medical Services, Ministry of Public Health, Trang 92000, Thailand.
Article Synopsis
- Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive soft tissue cancer with a poor prognosis, often diagnosed only after metastasis has occurred.
- Eccrine syringofibroadenoma (ESFA) is a rare skin lesion linked to eccrine ducts, with one subtype arising as a reaction to other inflammatory or neoplastic conditions.
- A case study is presented involving a 70-year-old man who had both UPS and reactive ESFA, highlighted by a specific skin lesion on his palm characterized by atypical cells and distinctive epidermal changes.
Beyond resorption: osteoclasts as drivers of bone formation.
Cell Regen
October 2024
Radboudumc, Dentistry - Regenerative Biomaterials, Philips Van Leijdenlaan 25, Nijmegen, 6525EX, the Netherlands.
Article Synopsis
- - Emerging research highlights that osteoclasts (OCs) have important roles in both bone formation and regeneration, beyond their traditional function of bone resorption, but their lifecycle and characteristics are still not fully understood.
- - Osteoclasts originate from osteoclast precursors (OCPs) derived from erythromyeloid progenitors (EMPs) during embryonic development and shift to being primarily sourced from hematopoietic stem cells (HSCs) postnatally, with their absence leading to serious bone structure issues.
- - The paper also discusses the challenges in isolating pure OC cultures and understanding their in vivo functions, as they interact closely with the immune system and blood vessels, and it offers insights into OCP
Histopathological features of subcutaneous and cutaneous mast cell tumors in dogs.
Acta Vet Scand
October 2024
Cancer Research Institute Ghent, Medical Research Building, University Hospital Ghent, Salisburylaan 133, Merelbeke, 9820, Belgium.
Article Synopsis
- - Mast cell tumors (MCTs) in dogs are categorized into cutaneous (cMCTs) and subcutaneous (scMCTs) types, with differences in tumor origin and the need for proper grading for prognosis.
- - A study analyzed 305 scMCTs and 1291 cMCTs, revealing distinct breed distributions and histopathological features, where scMCTs exhibited more severe characteristics and a higher likelihood of being classified as Kiupel high grade compared to cMCTs.
- - The findings indicate significant histopathological differences between scMCTs and cMCTs, but further research is needed to see how these differences might affect clinical outcomes in dogs.
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