Photosensitized luminescence of singlet (1 delta g) molecular oxygen with the maximum at 1272 nm has been found in solutions of psoralen, angelicin and 8-methoxypsoralen in CCl4. The luminescence excitation spectra, quantum yields of generation (gamma g) and rate constants of quenching (Kq) of 1 delta g by psoralens have been measured. The gamma g values 0,0055, 0,0026, 0,002 and Kq values 9 X 10(3), 11 X 10(3) and 12 X X 10(3) have been obtained for psoralen, angelicin and 8-methoxypsoralen, respectively. The role of 1 delta g in a photobiological action of psoralens is discussed.
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Cardiovasc Ther
January 2025
Department of Cardiology, The Fourth Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Myocardial infarction (MI), a severe cardiovascular disease, is the result of insufficient blood supply to the myocardium. Despite the improvements of conventional therapies, new approaches are needed to improve the outcome post-MI. Imperatorin is a natural compound with multiple pharmacological properties and potential cardioprotective effects.
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February 2025
Department of Fruit Tree Sciences, The Volcani Center ARO, 68 HaMaccabim Road, Rishon LeZion, 7505101, Israel.
Furanocoumarins (FCs) are plant defence compounds derived from the phenylpropanoid pathway via the coumarin umbelliferone that harbour some therapeutic benefits yet are the underlying cause of 'grapefruit-drug interactions' in humans. Most of the pathway genes have not been identified in citrus. We employed a genetic/Omics approach on citrus ancestral species and F1 populations of mandarin × grapefruit and mandarin × pummelo.
View Article and Find Full Text PDFTransfusion
January 2025
Laboratory of Cellular Hematology, DBCD, OBRR, CBER, FDA, Silver Spring, Maryland, USA.
Background: Pathogen reduction (PR) may be used as an alternative to gamma or x-ray irradiation (I) to prevent transfusion associated graft versus host disease (TA-GVHD) if the pathogen reduction technology has been shown to inactivate residual lymphocytes. However, as I is considered the gold standard for reducing the risk of TA-GVHD, some centers continue to perform I in addition to PR. This study investigated the effect of concurrent pathogen reduction and irradiation (PR/I) on the biochemical characteristics of apheresis platelets at day 1, 5, and 7 of storage at room temperature.
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December 2024
Transfusion Research Center, Belgian Red Cross Flanders, Ghent, Belgium.
Background: Human Platelet Lysate (hPL) is a platelet-derived and growth factor-rich supplement for cell culture. It can be prepared from surplus platelet concentrates initially intended for transfusion. Amotosalen-based photochemical pathogen inactivation of platelet concentrates is used in a number of blood establishments worldwide to minimize the risk of pathogen transmission from donor to patient.
View Article and Find Full Text PDFArch Dermatol Res
December 2024
Department of Dermatology, the Second Affiliated Hospital, The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan, University of Chinese Medicine, Changsha, 410005, Hunan, China.
Purpose: Melanin's pivotal role in skin protection and its overproduction leading to hyperpigmentation disorders highlight the necessity of regulating melanogenesis, with autophagy identified as a key degradation pathway. Imperatorin, a compound from Angelica dahurica, has been revealed to reduce melanin in epidermal keratinocytes, with the specific effects and mechanisms unknown. The purpose of this study was to investigate the mechanism by which imperatorin, reduces melanin production in HaCaT cells, with a focus on its potential role in promoting autophagy and regulating the PI3K/Akt signaling pathway.
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