Magnetic field (MF) intensifies the activity of penicillin-induced epileptogenic foci (EF) in the rabbit hippocamp. The same effect was obtained with gutimin. Injections of sodium hydroxybutyrate produced but little changes in hypersynchronous activity as compared to the data of control experiments. Combined influence of MF and gutimin on the rabbits somewhat reduced the quantity of the electrographic correlates of the seizures as compared with the results obtained with MF or gutimin alone. Meanwhile the use of MF coupled with sodium hydroxybutyrate reduced the number of the correlates and the amount of interictal epileptiform discharges as compared with these parameters in experiments where MF alone was applied or in control. It is assumed that MF induces slight hypoxia in the tissues thereby provoking an increase in the epileptogenic foci, whereas sodium hydroxybutyrate but not gutimin compensates for pathological action of MF.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Detection of epileptogenic zones in people with epilepsy using optimized EEG-fMRI.
Epilepsy Behav
January 2025
Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:
Purpose: Concurrent electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) have been used to assist in the presurgical localization of seizure foci in people with epilepsy. Our study aimed to examine the clinical feasibility of an optimized concurrent EEG-fMRI protocol.
Methods: The optimized protocol employed a fast-fMRI sequence (sampling rate = 10 Hz) with a spare arrangement, which allowed a time window of 1.
Glymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response.
Seizure
December 2024
Department of Neurology, Epilepsy Center, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Purpose: Glymphatic function has not been explored in patients with focal cortical dysplasia (FCD)-related epilepsy. This study aimed to investigate the glymphatic system's involvement in these patients and to evaluate its correlation with response patterns to different antiseizure medications (ASMs) using diffusion tensor imaging along the perivascular space (DTI-ALPS).
Methods: Fifty-two patients with FCD-related epilepsy (10 with drug-responsive epilepsy and 42 with drug-resistant epilepsy) and 24 healthy controls (HC) were included.
ESR Essentials: Image evaluation of patients with seizures and epilepsy-practice recommendations by the European Society of Neuroradiology.
Eur Radiol
December 2024
Department of Neuroradiology, Medical Center-University of Freiburg, Freiburg, Germany.
Epilepsy, a neurological disorder characterised by recurrent seizures, poses significant challenges in diagnosis, treatment, and management. Understanding the underlying causes and identifying precise anatomical locations of epileptogenic foci are critical for effective management strategies, particularly in drug-resistant patients. Neuroimaging techniques, particularly magnetic resonance (MR), play a pivotal role in the evaluation of epilepsy patients, offering insights into structural abnormalities, epileptogenic lesions, and functional alterations within the brain.
View Article and Find Full Text PDFTSPO-PET in pre-surgical evaluations: Correlation of neuroinflammation and SEEG epileptogenicity mapping in drug-resistant focal epilepsy.
Epilepsia
December 2024
Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Université Paris-Saclay, CEA, CNRS, Inserm, Orsay, France.
Objectives: Resective surgery in drug-resistant focal epilepsy (DRFE) requires extensive evaluation to localize the epileptogenic zone (EZ). When non-invasive phase 1 assessments (electroencephalography, EEG; magnetic resonance imaging, MRI; and F-Fluorodeoxyglucose-positron emission tomography, [F]FDG-PET) are inconclusive for EZ localization, invasive investigations such as stereo-EEG (SEEG) are necessary. Epileptogenicity maps (Ems) visualize the EZ using SEEG-identified ictal high-frequency oscillations (iHFOs).
View Article and Find Full Text PDFIntraoperative identification of epileptogenic foci using handheld histopathologic endoscopy: a case report.
J Neurol
December 2024
Department of Neurosurgery, Huashan Hospital, National Center for Neurological Disorders, Fudan University, No. 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!