In a retrospective analysis of cases of surgically confirmed infantile hypertrophic pyloric stenosis (IHPS) in South Glamorgan in the decade 1970-9 the incidence rose sharply in 1976 reflecting a general increase reported throughout Wales and from other parts of the United Kingdom. The increase was mainly among boys and although it occurred at a time when breast feeding had become more popular, it affected bottle fed infants more than breast fed infants. The apparent correlation between incidence of IHPS and incidence of breast feeding may coincidental and changes in infant milk formulae that became general in 1976 may be more important. An appreciable excess of first born infants with IHPS was noted but there was no correlation between birthweight and IHPS. Variations according to month of birth did not coincide with true seasonal variation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1628343 | PMC |
| http://dx.doi.org/10.1136/adc.58.8.586 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Splenomegaly and progressive neurologic involvement: Think about Niemann-Pick type C disease.
Pediatr Int
December 2024
Medical Faculty, Department of Pediatric Metabolism and Nutrition, Ege University, Izmir, Türkiye.
Background: Niemann-Pick type C (NPC) disease is a lysosomal storage disease with visceral organ involvement and neurological and psychiatric symptoms. This study presents the clinical and laboratory findings of NPC cases involving three novel variants.
Methods: The clinical and laboratory findings were reviewed retrospectively between February 2006 and December 2022.
The safety profile of azithromycin in pediatrics: a pharmacovigilance disproportionality analysis.
Expert Opin Drug Saf
December 2024
Department of Pharmacy, DaLi University First Affiliated Hospital, DaLi City, Yunnan Province, China.
Aim: To mine and analyze adverse drug events (ADEs) signals of azithromycin use in children in the real world to inform the safety assessment of azithromycin use in children.
Methods: ADE reports from the FDA Adverse Event Reporting System (FAERS) involving children (0-17 years) with azithromycin as the primary suspected drug from 2004 to early 2024 were extracted. ADEs were categorized using MedDRA, and signal detection was conducted using Reporting Odds Ratio (ROR) and Proportional Reporting Ratio (PRR).
Navigating Pompe Disease Assessment: A Comprehensive Scoping Review.
Cureus
November 2024
Rare Diseases, Rare Diseases Community (RDCom), Buenos Aires, ARG.
Pompe disease (PD) is a rare progressive autosomal recessive disorder resulting from the deficiency of acid alpha-glucosidase (GAA) enzyme activity. Due to its multisystemic involvement, PD leads to significant morbidity and impacts patients' quality of life. Despite the availability of approved disease-modifying treatments, the prompt diagnosis and management of PD, which are crucial for patient outcomes, still present several challenges.
View Article and Find Full Text PDFLong-term Gastrointestinal Sequelae in Children who Underwent Pyloromyotomy for Infantile Hypertrophic Pyloric Stenosis.
J Pediatr Surg
November 2024
Department of Pediatric Surgery, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, Amsterdam, the Netherlands; Amsterdam UMC, Amsterdam Reproduction and Development Research Institute, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
Article Synopsis
- The study aimed to assess the long-term gastrointestinal effects of pyloromyotomy in children who had undergone this surgery for infantile hypertrophic pyloric stenosis (IHPS) from 2007 to 2017.
- A questionnaire, including the Pediatric Quality of Life Inventory™ Gastrointestinal symptoms module, was completed by 199 participants, revealing that their GI symptoms scores were similar to those of healthy peers.
- The results suggest that long-term GI issues after pyloromyotomy are rare, indicating no significant difference in health outcomes between these children and healthy controls, which can help inform parents and lessen the need for extensive follow-up care.
RASopathies in Cardiac Disease.
Annu Rev Med
November 2024
1Department of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, New York, USA; email:
RASopathies are a group of clinically overlapping autosomal dominant disorders caused primarily by mutations in genes that reside along the canonical Ras-mitogen-activated protein kinase signaling cascade. Though individually rare, collectively, these disorders constitute one of the largest families of congenital disorders worldwide, particularly for infantile hypertrophic cardiomyopathy. Significantly, despite almost five decades of RASopathy research, therapeutic options remain limited and focused primarily on treating symptoms rather than disease etiology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!