The maximum O2 intake (max VO2) is the best test in order to describe a subject's physical capacity. It is difficult to measure directly. The Astrand normogram gives an indirect and approximate measurement. Two more exact methods are suggested: the maximum developed power in Kg (W/Kg) and the second minute recovery index (iR2) = (formula; see text) where fc2 is the cardiac frequency two minutes after exertion. The correlation is r = 0.94 (p less than 0.001) between max VO2 and W/Kg. The correlation is r = 0.94 (p less than 0.001) between max VO2 and iR2. The iR2 can be determined for a sub-maximal performance at 80 per cent of the maximum and has a high correlation with the max VO2. The max VO2 can thus be determined by these two methods which appear to be the most reliable of the regular tests of physical capacity.
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Antioxidants (Basel)
December 2024
Department of Pharmacological Biotechnology, Medical University of Lodz, 90-152 Lodz, Poland.
Ginseng has multi-directional pharmacological properties. Some data suggest that ginseng can enhance physical endurance, which, in turn, leads to protection of the cardiovascular system. However, not all experiments are conclusive.
View Article and Find Full Text PDFERJ Open Res
January 2025
Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Background: In patients with COPD, preventive treatment with acetazolamide reduces adverse health effects during altitude travel. We investigated whether preventive acetazolamide treatment modifies exercise performance in COPD patients going to high altitude.
Methods: In this randomised, double-blind trial, lowlanders with COPD, forced expiratory volume in 1 s (FEV) 40-80% predicted, were assigned to acetazolamide (375 mg per 24 h) or placebo treatment starting 24 h before ascent and while staying at 3100 m.
Echo Res Pract
January 2025
School of Human Kinetics, Trinity Western University, CANIL Building, Rm. 115 22500 University Drive, Langley, BC, V2Y 1Y1, Canada.
Background: Aerobic capacity measured by maximal oxygen uptake (VOmax) is related to functional capacity and is a strong independent predictor of all-cause and disease-specific mortality. Sex-specific cardiac and vascular responses to endurance training have been observed, however, their relative contributions to VOmax are less understood. The purpose of this study was to evaluate sex-specific ventricular-vascular interactions associated with VOmax in healthy males and females.
View Article and Find Full Text PDFJACC Adv
January 2025
Division of Adult Congenital Heart Disease, Duke University Health System, Durham, NC, USA.
Background: Patients with Fontan circulation are frail and experience multisystem dysfunction including impaired exercise capacity, low resting and exercise-augmented cardiac output, and progressive liver fibrosis. However, common underlying biochemical abnormalities or disease-specific biomarkers have not been well-described.
Objectives: We wish to investigate Fontan and their matched healthy subjects using a nontargeted, followed by targeted metabolomic analysis.
J Appl Physiol (1985)
January 2025
Department of Human Physiology, Gonzaga University, Spokane, Washington, United States.
We tested the hypothesis that power at maximal metabolic steady state is similar between fitness matched men and women. Eighteen participants (9 men, 9 women) performed a cycling graded exercise test for maximal oxygen consumption (V̇O). Men and women were matched for V̇O normalized to fat free mass (FFM), which was 50.
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