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Cervical Cancer Screening in Women With Physical Disabilities.
JAMA Netw Open
January 2025
Department of Family Medicine, University of Michigan, Ann Arbor.
Importance: Cervical cancer screening is a crucial public health intervention, but screening disparities exist for women with physical disabilities (WWPD).
Objective: To explore the experiences of WWPD with both traditional speculum examination-based screening and at-home self-sampling for cervical cancer screening.
Design, Setting, And Participants: This qualitative study enrolled 56 WWPD to test self-sampling kits, provide feedback via a survey, and participate in a qualitative interview.
Disclosing the impact of metformin and methotrexate in adjuvant arthritis in female rats: molecular docking and biochemical insights on visfatin.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Pharmacology Department, Medical and Clinical Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt.
Rheumatoid arthritis (RA) is one of the most common systemic autoimmune inflammatory diseases, with a progressive etiology that results in serious complications and a higher chance of early death. Visfatin, an adipokine, is correlated with disease pathologic features and becomes a key biomarker and therapeutic target for RA. This study aimed to evaluate the anti-arthritic activity of metformin (an antidiabetic drug with anti-inflammatory activities) and methotrexate (the first choice for disease-modifying antirheumatic drugs in RA, with diverse adverse effects) in complete Freund's adjuvant (CFA)-induced arthritis in female rats.
View Article and Find Full Text PDFBackground: Despite guideline recommendations, few institutions have implemented clinical pathways that incorporate frailty into routine decision-making for patients undergoing radical cystectomy (RC). This paper presents an integrated clinical pathway designed to address the needs of frail patients undergoing RC. The purpose of the study is to determine whether a multifaceted prevention programme that tailors interventions to the syndromic components of frailty can improve postoperative morbidity and recovery time for patients.
View Article and Find Full Text PDFElectroencephalogram biomarkers as predictors of mortality and functional recovery in patients with severe traumatic brain injury: Protocol study.
MethodsX
June 2025
Neurorehabilitation and Neuromodulation Laboratory, Department of Physiological Sciences, Federal University of Espírito Santo, City of Vitória, ES, Brazil.
Traumatic brain injury (TBI) is a global public health condition that causes cognitive and behavioral deficits. This protocol assesses the potential of quantitative electroencephalogram (EEG) biomarkers, associated with inflammatory indicators, to predict mortality and functional recovery in patients with severe TBI. Through continuous monitoring and analysis of abnormal brain activity patterns, the protocol aims to personalize therapeutic interventions and improve patient quality of life.
View Article and Find Full Text PDFComparison of WALANT and general anaesthesia for trapeziectomy and abductor pollicis longus hammock ligamentoplasty.
J Hand Microsurg
January 2025
Etlik City Hospital, Orthopedics and Neurology Hospital, Orthopedics Clinic, Ankara, Turkiye.
Background: Trapeziectomy and abductor pollicis longus hammock ligamentoplasty may be performed in the surgical management of trapeziometacarpal joint osteoarthritis (TMC OA). Several anaesthesia techniques are available for TMC joint surgery, including wide-awake local anaesthesia no tourniquet (WALANT), regional anaesthesia, and general anaesthesia (GA). The aim of this study was to compare the clinical outcomes of trapeziectomy and abductor pollicis longus hammock ligamentoplasty performed under WALANT versus GA.
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