[The adjuvant effect of synthetic glycopeptides on humoral immune response to thymus-dependent antigen].

The comparative study of 5 analogs of muramyldipeptide (MDP) on primary and secondary immune response to bovine serum albumin has been studied. The adjuvant activity of the MDP analogs has been shown to be closely connected with their structure. Thus, the replacement of glutamine by aspartic acid leads to the loss of adjuvant properties, and the replacement of L-alanine by its stereoisomer causes a perceptible decrease in these properties. The most active analog of MDP is GlcNAc-MurNAc-Ala-D-Glu-NH2 which produces a stimulating effect when introduced parenterally (subcutaneously and intraperitoneally) in a dose of 1 microgram, and orally in a dose of 100 micrograms.