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Characterization of Factors Associated With Death in Deceased Patients With Mitochondrial Disorders: A Multicenter Cross-Sectional Survey.
Neurology
February 2025
Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, People's Republic of China.
Background And Objectives: Mitochondrial disorders are multiorgan disorders resulting in significant morbidity and mortality. We aimed to characterize death-associated factors in an international cohort of deceased individuals with mitochondrial disorders.
Methods: This cross-sectional multicenter observational study used data provided by 26 mitochondrial disease centers from 8 countries from January 2022 to March 2023.
Detecting low birth weight is crucial for early identification of at-risk pregnancies which are associated with significant neonatal and maternal morbidity and mortality risks. This study presents an efficient and interpretable framework for unsupervised detection of low, very low, and extreme birth weights. While traditional approaches to managing class imbalance require labeled data, our study explores the use of unsupervised learning to detect anomalies indicative of low birth weight scenarios.
View Article and Find Full Text PDFMaternal and Infant Outcomes in a Subset of Patients with Sickle Cell Disease in South Carolina.
South Med J
February 2025
the Department of Public Health Sciences.
Objectives: Sickle cell disease (SCD), which disproportionately affects minorities, increases complications during pregnancy. Severe maternal mortality is increased in women with SCD, including morbidity related to the disease and other nondisease-related complications. It also can have devastating complications for fetuses, with increases in premature birth and low birth weight.
View Article and Find Full Text PDFSocioeconomic characteristics and relapse-free and overall survival from childhood cancer - a nationwide study based on data from the Danish Childhood Cancer Registry.
Acta Oncol
January 2025
Cancer Survivorship, Danish Cancer Institute, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Denmark; Department of Clinical Oncology & Palliative Care, Zealand University Hospital, Naestved, Denmark.
Background And Purpose: Over the past decades, childhood cancer survival has increased substantially in Europe, including Denmark. However, families with fewer social resources may have benefitted less from these improvements. In this nationwide register-based study, we assessed associations between parental socioeconomic position (SEP) and 5-year relapse-free survival (RFS) and overall survival (OS) in childhood cancer patients.
View Article and Find Full Text PDFMortality in the families of children during the COVID-19 pandemic: evidence from a repeated cross-sectional study of children in the United States.
BMC Public Health
January 2025
Division of General Medicine, University of Michigan Medical School, Ann Arbor, USA.
Background: Modeling studies suggest that hundreds of thousands of U.S. children have lost caregivers since the COVID-19 pandemic began.
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