The kidneys of 117 patients were examined before and after (immediately until several weeks) a telecobalt irradiation of the aortal lymph nodes. In 36 out of them, another control examination could be performed after 1 1/2 years. In 17 patients, the early examinations showed functional troubles of the kidneys which regressed in nine cases. The late examinations showed in 19 cases functional restrictions which have to be considered to be irreversible. The conclusion must be drawn that it is necessary to examine the kidneys before and until several years after a radiotherapy of the aortal lymph nodes and that the dose distribution has to be optimized with respect to a conservation of the kidneys, as far as this is oncologically possible.
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J Maxillofac Oral Surg
December 2024
Department of Dentistry, Sri Devaraj Urs Medical College, Tamaka, Kolar India.
Osteoradionecrosis (ORN) is a nemesis of radiotherapy which adversely affects the life of an individual. It is more often seen with conventional external beam radiotherapy using telecobalt machine. Newer radiotherapy techniques are being used in developed nations to circumvent its inherent disadvantages.
View Article and Find Full Text PDFJ Med Phys
September 2024
Centre for Cosmology, Astrophysics and Space Science, GLA University, Mathura, Uttar Pradesh, India.
Aim: This article examines India's present radiotherapy (RT) machine status and requirements, geographical distribution, and infrastructure need in six regional areas, which include 31 member states and union territories (UTs). It also considers the influence of the COVID-19 pandemic on India's teletherapy sector.
Materials And Methods: Data from reliable resources, including Atomic Energy Regulatory Board, Global Cancer Observatory, and Directory of Radiotherapy Centres databases, were used to analyze the current status of RT machine (RTM) density, regional disparity, and COVID-19 impact on infrastructure growth-rate.
Rep Pract Oncol Radiother
June 2024
Department of Radiation Oncology, Christian Medical College Vellore, Vellore, India.
Background: Gamma-H2AX immunofluorescence assay has gained popularity as a DNA double strand break marker. In this work, we have investigated the potential use of gamma H2AX immunofluorescence assay as a biological dosimeter for estimation of dose in our institution.
Materials And Methods: Seven healthy individuals were selected for the study and the blood samples collected from the first five individuals were irradiated to low doses (0-10 cGy) and high doses (50-500 cGy) in a telecobalt unit.
J Egypt Natl Canc Inst
June 2024
Department of Physics, University of Peshawar (UOP), Peshawar, KPK, Pakistan.
Background: Innovations in cancer treatment have contributed to the improved survival rate of cancer patients. The cancer survival rates have been growing and nearly two third of those survivors have been exposed to clinical radiation during their treatment. The study of long-term radiation effects, especially secondary cancer induction, has become increasingly important.
View Article and Find Full Text PDFCancer Rep (Hoboken)
March 2024
Depatment of Pathology, Institute of Post Graduate Medical Education & Research and SSKM Hospital, Kolkata, India.
Background: Metaplastic Breast Cancer (MpBC) is an exceedingly rare entity, accounting for less than 1% of all malignant breast tumours. Predominantly triple-negative, they are notorious for their chemoresistance, high rates of recurrence and decreased disease-free survival (DFS). All this contributes significantly to BC mortality and results in poor prognostic implications.
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