The work demonstrates that after the injection of a heterogenous antigen into rabbits the appearance of antibodies is followed by the "spontaneous" formation of anti-idiotypic antibodies. These anti-antibodies, detected by means of several serological reactions, are specific and have an idiotypic character. Circulating antibody--anti-idiotypic antibody complexes have been detected in the blood of the animals. The injection of autologous anti-idiotypic antibodies into the immunized animals ensures the stimulation of the formation of antibodies and anti-idiotypic antibodies. Immunological memory with respect to anti-idiotypic antibodies develops in the body of the immunized animals.
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Acumen Pharmaceuticals, Charlottesville, VA, USA.
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Rev Paul Pediatr
January 2025
Universidade Federal de São Paulo, São Paulo, SP, Brazil.
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BMJ Open
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Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
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View Article and Find Full Text PDFSystematic review of omalizumab for refractory clonal and non-clonal mast cell activation syndrome.
Allergy Asthma Proc
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From the Section of Allergy, Asthma and Immunology, Medicine and Pediatrics, Pennsylvania State University School of Medicine, Hershey, Pennsylvania and.
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