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The burden of headache disorders among medical students in Vietnam: estimates from a cross-sectional study with a health-care needs assessment.
J Headache Pain
January 2025
Department of Internal Medicine, VNU University of Medicine and Pharmacy, Hanoi, Vietnam.
Background: In our previous study, we demonstrated that headaches are highly prevalent among medical students in Vietnam. In the present study, we provide estimates of the associated symptom burden and impaired participation, utilizing these estimates to assess headache-related healthcare needs within this population.
Methods: The study followed the standardized methodology established by the Global Campaign against Headache.
Time and headache: Insights into timing processes in primary headache disorders for diagnosis, underlying pathophysiology and treatment implications.
Cephalalgia
November 2024
Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Article Synopsis
- Time plays a critical role in diagnosing headache disorders and understanding their underlying mechanisms, highlighting the need for effective timing analysis in headache research.
- A review of studies covering primary headache types—migraine, tension-type headache, and cluster headache—reveals distinct timing patterns, such as circadian rhythms in migraines and night-time occurrences in cluster headaches.
- Understanding these time patterns can improve the phenotyping, management, and treatment of headache disorders, pointing towards new, personalized approaches in headache care.
Insights from triggers and prodromal symptoms on how migraine attacks start: The threshold hypothesis.
Cephalalgia
October 2024
Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Article Synopsis
- The prodrome phase of a migraine attack occurs 24-48 hours before the headache and involves symptoms that can be mistaken for triggers.
- This review analyzes existing studies to clarify the distinction between prodromal symptoms and migraine triggers, using clinical and neurophysiological data.
- Understanding the interaction between brain activity during the prodromal phase and potential triggers is essential for improving migraine management and exploring their underlying mechanisms.
The influence of pharmacodynamics and pharmacokinetics on the antimigraine efficacy and safety of novel anti-CGRPergic pharmacotherapies: a narrative review.
Expert Opin Drug Metab Toxicol
January 2025
Departamento de Farmacobiología, Cinvestav-Coapa, Ciudad de México, México.
Article Synopsis
- Migraine is a complicated disorder, with calcitonin gene-related peptide (CGRP) playing a key role in its understanding and the development of new treatments like gepants and monoclonal antibodies, which are effective and safe for patients.
- A narrative review investigated CGRP's role in migraines and analyzed the effects of CGRP-targeted medications regarding how they work and how the body processes them.
- While current CGRP medications show effectiveness, they have limitations, like side effects and varying efficacy among patients; some patients' migraines may persist due to the complexity of migraine mechanisms and medication properties.
Pain from Internal Organs and Headache: The Challenge of Comorbidity.
Diagnostics (Basel)
August 2024
Headache Center, Geriatrics Clinic, SS Annunziata Hospital, 66100 Chieti, Italy.
Headache and visceral pain are common clinical painful conditions, which often co-exist in the same patients. Numbers relative to their co-occurrence suggest possible common pathophysiological mechanisms. The aim of the present narrative review is to describe the most frequent headache and visceral pain associations and to discuss the possible underlying mechanisms of the associations and their diagnostic and therapeutic implications based on the most recent evidence from the international literature.
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