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Aim: Chronic cocaine use is associated with decreases in neuroactive steroid levels. These adaptations may contribute to continued cocaine use and high relapse risk in individuals with cocaine use disorder (CUD). Thus, this pilot study assessed chronic treatment with 2 supraphysiologic doses of the neuroactive steroid precursor pregnenolone (PREG, 300 mg/day; 500 mg/day) to boost endogenous neuroactive steroid levels and assess its impact on provoked craving and cocaine use outcomes in an 8-week trial in men and women with CUD.
View Article and Find Full Text PDFMetal allergy as a persistent factor for psoriasis.
J Prosthodont Res
January 2025
Division of Bio-prosthodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori, Chuo-ku, Niigata Japan.
Purpose: Psoriasis is a complex, chronic inflammatory keratosis of unclear origin that is challenging to treat. In patients with psoriasis suspected of having metal allergies, the removal of oral metallic prostheses contributes to the alleviation of psoriasis symptoms. However, the relationship and mechanism of the metal removal effect and improvement in psoriasis symptoms in patients with metal allergies are unknown.
View Article and Find Full Text PDFSacroiliac Joint: Function, Pathology, Treatment, and Contribution to Outcomes in Spine and Hip Surgery.
J Bone Joint Surg Am
December 2024
Division of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.
Article Synopsis
- Low back pain affects up to 84% of people and is the top cause of disability in the U.S.; sacroiliac joint dysfunction accounts for 10% to 38% of these cases.
- A thorough examination of the sacroiliac joint and nearby areas is essential for diagnosing pain, using multiple provocation tests and imaging techniques for accurate results.
- Treatment options for low back pain range from non-invasive methods like medication and physiotherapy to more invasive procedures, but caution is needed as certain surgeries can lead to further degeneration of the sacroiliac joint and hip.
Subcultural Representations of Perpetrators and Victims of Crime and Violence Associated with Mental Disorders.
Rev Colomb Psiquiatr (Engl Ed)
December 2024
History of Medicine Unit, Department of Social and Health Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain.
Introduction And Objectives: The beliefs and opinions of the general population are based substantially on mass media, which often equates mental disorders with violence and criminality. These stigmatising depictions contribute to the development and persistence of negative attitudes towards people with psychiatric conditions. The objective was to examine, through popular music, the subcultural representations of crime and violence in the context of mental disorders, focusing on depictions of victims and offenders.
View Article and Find Full Text PDFLow Prostaglandin E but High Prostaglandin D, a Paradoxical Dissociation in Arachidonic Acid Metabolism in Aspirin-Exacerbated Airway Disease: Role of Airway Epithelium.
J Clin Med
December 2024
Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, 08907 Barcelona, Spain.
In patients with aspirin-exacerbated respiratory disease (AERD), there is disparate regulation of prostaglandin E2 (PGE) and prostaglandin D (PGD). Both prostanoids are synthesised by cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2). However, while the basal synthesis of PGE tends to decrease, that of PGD increases in patients with AERD.
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