A 74-year-old woman, on lithium carbonate treatment, developed symptomatic sinus node dysfunction and central nervous toxicity, which disappeared after discontinuation of the drug and when serum lithium fell from 2 to 1.27 mEq/L. Our review of the literature demonstrates that sinus node abnormalities can occur both in presence of therapeutic and toxic serum lithium levels and are frequently asymptomatic and completely reversible. All patients receiving lithium should have their pulse regularly recorded and the drug should be promptly discontinued if severe bradycardia or other rhythm disturbances appeared during the treatment.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
An Unusual ECG Finding during Adenosine Stress Myocardial Perfusion Imaging.
Indian J Nucl Med
November 2024
Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Adenosine is extensively utilized in myocardial stress perfusion imaging for the detection and risk stratification of coronary artery disease. It has a well-established safety profile. The majority of the undesirable effects experienced during adenosine infusion are transient (owing to its brief half-life of ~10 s) and arise from the stimulation of receptors in the atrio-ventricular (AV) node (AV block) and bronchial smooth muscles (bronchospasm).
View Article and Find Full Text PDFMinimally Invasive Repair of a Sinus Node Artery Aneurysm With a Fistula Into the Right Atrium.
Ann Thorac Surg Short Rep
March 2024
Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
A coronary artery aneurysm arising from a sinus node artery with a fistula is an extremely rare congenital anomaly. We report a rare case of a minimally invasive repair of a sinus node artery aneurysm with a fistula in the right atrium.
View Article and Find Full Text PDFiPSC-Derived Biological Pacemaker-From Bench to Bedside.
Cells
December 2024
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Induced pluripotent stem cell (iPSC)-derived biological pacemakers have emerged as an alternative to traditional electronic pacemakers for managing cardiac arrhythmias. While effective, electronic pacemakers face challenges such as device failure, lead complications, and surgical risks, particularly in children. iPSC-derived pacemakers offer a promising solution by mimicking the sinoatrial node's natural pacemaking function, providing a more physiological approach to rhythm control.
View Article and Find Full Text PDFAtrial Fibrillation-Related Bradycardia and/or Bradycardia-Related Atrial Fibrillation: When and How to Intervene.
Curr Vasc Pharmacol
January 2025
Department of Cardiology, Athens University School of Medicine, Athens, Greece.
Introduction/objective: Atrial fibrillation (AF) could present with slow ventricular-response; bradycardia could facilitate the emergence of AF. The conviction that one "does not succumb" from bradycardia as an escape rhythm will emerge unless one sustains a fatal injury following syncope is in stark difference with ventricular tachyarrhythmia (VA), which may promptly cause cardiac arrest. However, this is not always the case, as a life-threatening situation may emerge during the bradycardic episode, i.
View Article and Find Full Text PDFThe impact of common and rare genetic variants on bradyarrhythmia development.
Nat Genet
January 2025
Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA.
To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respectively.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!