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Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances.
Arch Toxicol
January 2020
In Vitro Toxicology and Biomedicine, Department Inaugurated By the Doerenkamp-Zbinden Chair Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany.
The first in vitro tests for developmental toxicity made use of rodent cells. Newer teratology tests, e.g.
View Article and Find Full Text PDFAssociations of IL-4, IL-6, and IL-12 levels in peripheral blood with lung function, cellular immune function, and quality of life in children with moderate-to-severe asthma.
Medicine (Baltimore)
March 2017
Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, Shandong Province, PR China.
Background: Pediatric asthma has gained increasing concerns with poorly understood pathogenesis. The purpose of this study was to explore the associations of interleukin-4 (IL-4), IL-6, and IL-12 levels in peripheral blood (PB) with lung function, cellular immune function, and children's quality of life (QOL) with moderate-to-severe asthma.
Methods: A total of 1158 children with moderate-to-severe asthma (the experimental group) and 1075 healthy children (the control group) were recruited for our study.
The humoral response to Plasmodium falciparum VarO rosetting variant and its association with protection against malaria in Beninese children.
Malar J
October 2010
Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, F-75015 Paris, France.
Background: The capacity of Plasmodium falciparum-infected erythrocytes to bind uninfected erythrocytes (rosetting) is associated with severe malaria in African children. Rosetting is mediated by a subset of the variant surface antigens PfEMP1 targeted by protective antibody responses. Analysis of the response to rosette-forming parasites and their PfEMP1 adhesive domains is essential for understanding the acquisition of protection against severe malaria.
View Article and Find Full Text PDFRosetting in Plasmodium falciparum: a cytoadherence phenotype with multiple actors.
Transfus Clin Biol
September 2008
Unité d'immunologie moléculaire des parasites, Institut Pasteur, 28, rue du Docteur-Roux, 75724 Paris cedex 15, France.
The capacity of Plasmodium falciparum-infected red blood cells to bind uninfected red blood cells ("rosetting") has been associated with high parasite density in numerous geographic areas and with severe malaria in African children. We summarize here the associations that have emerged from field studies and describe the various experimental models of rosetting that have been developed. A variety of erythrocyte receptors, several serum factors and a number of rosette-mediating PfEMP1 adhesins have been identified.
View Article and Find Full Text PDFBrain tumor inhibition in experimental model by restorative immunotherapy with a corpuscular antigen.
Indian J Exp Biol
August 2003
Immunology Section, Department of Pathology, University College of Medicine, 244B, A.J.C. Bose Road, Kolkata 700020, India.
In view of the advances in our understanding of anti-tumor immune response, it is now tempting to contemplate the development of immunotherapies for malignant brain tumors, for which no effective treatment exists. Immunotherapy, with agents known as biological response modifiers (BRMs) are thus gaining increasing interest as the fourth modality of treatment. A non-specific BRM, sheep erythrocytes (SRBC) when administered (ip, 7% PCV/V, 0.
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