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Strain-Controlled Thermal-Mechanical Fatigue Behavior and Microstructural Evolution Mechanism of the Novel Cr-Mo-V Hot-Work Die Steel.
Materials (Basel)
January 2025
School of Materials Science and Engineering, Henan University of Science and Technology, Luoyang 471023, China.
In response to the intensifying competition in the mold market and the increasingly stringent specifications of die forgings, the existing 55NiCrMoV7 (MES 1 steel) material can no longer meet the elevated demands of customers. Consequently, this study systematically optimizes the alloy composition of MES 1 steel by precisely adjusting the molybdenum (Mo) and vanadium (V) contents. The primary objective is to significantly enhance the microstructure and thermal-mechanical fatigue performance of the steel, thereby developing a high-performance, long-life hot working die steel designated as MES 2 steel.
View Article and Find Full Text PDFD-Ala2-GIP (1-30) promotes angiogenesis by facilitating endothelial cell migration via the Epac/Rap1/Cdc42 signaling pathway.
Cell Signal
January 2025
Department of Respiratory and Critical Care Medicine, Affiliated Hospital and Medical School of Nantong University, Nantong, Jiangsu Province 226001, China. Electronic address:
Angiogenesis, a meticulously regulated process essential for both normal development and pathological conditions, necessitates a comprehensive understanding of the endothelial mechanisms governing its progression. Leveraging the zebrafish model and NgAgo knockdown system to identify target genes influencing angiogenesis, our study highlights the significant role of gastric inhibitory polypeptide (GIP) and its receptor (GIPR) in this process. While GIP has been extensively studied for its insulinotropic and glucagonotropic effects, its role in angiogenesis remains unexplored.
View Article and Find Full Text PDFSeasonal role of a specialist predator in rodent cycles: Ermine-lemming interactions in the High Arctic.
Ecology
January 2025
Département de Biologie & Centre d'Études Nordiques, Université Laval, Québec, Quebec, Canada.
The exact mechanisms behind population cycles remain elusive. An ongoing debate centers on whether predation by small mustelids is necessary and sufficient to generate rodent cycles, as stipulated by the specialist predator hypothesis (SPH). Specifically, the SPH predicts that the predator should respond numerically to the abundance of its prey with a delay of approximately one year, leading to delayed density-dependence in the dynamics of the prey population.
View Article and Find Full Text PDFLaser-chemical composite manufacturing of biomimetic stepped armor functional metal surface with wear resistance and anti-icing characteristics.
J Colloid Interface Sci
January 2025
School of Mechanical Engineering, Jiangsu University, Zhenjiang 212013 China.
Superhydrophobic surfaces have been demonstrated to exhibit excellent anti-icing effects, but they are susceptible to the loss of ice repellency as a result of external impacts. This paper proposes a novel bionic armour structure that combines an armour structure with an arrowroot bionic structure. A composite method combining laser etching and chemical modification was employed to achieve superhydrophobicity on the surface of the aluminium alloy.
View Article and Find Full Text PDFIdentifying people at risk of rheumatoid arthritis in primary care: qualitative study.
Br J Gen Pract
January 2025
University of Leeds Faculty of Medicine and Health, Leeds Institute of Health Sciences, Leeds, United Kingdom
Background: Identification of rheumatoid arthritis (RA) in primary care is challenging and often delayed. Anti-cyclic citrullinated peptide (anti-CCP) antibody testing of people presenting to primary care with new-onset musculoskeletal symptoms without synovitis could help address this; those testing positive are at increased risk of developing RA.
Aim: To explore how primary care clinicians currently identify and refer patients with suspected RA, and the behaviours required to implement a prediction model for guiding targeted anti-CCP testing for non-specific musculoskeletal symptoms in primary care.
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