Fifty-one patients were analyzed after a randomized double-blind study comparing Hexabrix and Renografin 60 in peripheral arteriography. The arteriographic studies and the volumes of contrast material used in both groups were similar. Hexabrix caused significantly less pain and discomfort than Renografin 60, and the diagnostic quality of the radiographs was comparable. A slightly higher incidence of minor side effects was noted in the Hexabrix group, mostly nausea and vomiting and urinary retention.
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http://dx.doi.org/10.2214/ajr.140.5.975 | DOI Listing |
Radiat Med
January 2003
Department of Radiology, Kyoto City Hospital, Mibu, Japan.
Purpose: It has been demonstrated that iodinated contrast medium (CM) causes the release of potassium into the intravascular spaces, resulting in an increase of serum potassium. The purpose of the present study was to assess the effect of mixing ratio on potassium release rates by using various mixing ratios with human blood in vitro.
Materials And Methods: Fresh human blood from 52 patients was mixed in vitro with iodinated CM at ratios ranging from 10:2 (blood:CM) to 10:10.
Chest
October 1999
UBC Pulmonary Research Laboratory, St. Paul's Hospital, 1081 Burrard St, Vancouver, BC, Canada.
Study Objectives: To determine if the vasodilatory response to the intracoronary injection of ionic and nonionic contrast media in intact pigs is dependent on nitric oxide (NO). The mechanisms responsible for inducing the increase in coronary blood flow in response to the intracoronary injection of contrast media during angiography are still not entirely understood. There is evidence to suggest that the response could be partially mediated by NO.
View Article and Find Full Text PDFEur J Radiol
July 1999
Department of Radiology, Sumitomo Hospital, Osaka, Japan.
The clearance of three iodinated contrast media (CM) and three MR-CM through two kinds of hemodialysis (HD) membranes were investigated in vitro. All three MR-CM are not only injected intravenously and mainly secreted through the kidney, but also now commercially available. Each of the six CM showed significantly higher clearance with one kind of HD membrane, with a larger pore size, than that with the other.
View Article and Find Full Text PDFEur Radiol
November 1999
Department of Radiology, Kyoto City Hospital, 1-2 Higashi-takada-cho, Mibu, Nakagyo-ku, Kyoto 604-8845, Japan.
It has been demonstrated that an iodinated contrast medium (CM) causes release of potassium into blood vessel lumina, resulting in an increase in serum potassium. The purpose of the present study was to assess whether this potassium release is due to hemolysis. Fresh human blood was mixed in vitro with CM at a ratio of 10:2.
View Article and Find Full Text PDFScand J Immunol
April 1997
Department of Radiology, Helsinki University Central Hospital, Finland.
The authors examined the effect of four different kinds of contrast media (ionic/non-ionic, monomer/dimer) on the activation of the complement (C) system (haemolytic activity and anaphylatoxin generation) in vitro. In addition, the authors compared the effect of contrast media on inulin-mediated generation of the anaphylatoxin derivative C3a des Arg in sera from urticarial reactors and their non-reacting controls. It was observed that the incubation of commercial iohexol, ioxaglate, iodixanol and meglumin amidotriz solutions in normal human serum (NHS) resulted in a dose-dependent decrease in the haemolytic activity of the alternative C pathway.
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