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An optimized caries model of in rats and its application for evaluating prophylactic vaccines.
Hum Vaccin Immunother
December 2024
Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Dental caries is a prevalent oral disease that mainly results from . Susceptibility to decreased rapidly after weaning in a well-known rat model. However, owing to the lack of time to establish protective immunity ahead of challenge, the weaning rat model is suboptimal for assessing prophylactic vaccines against infection.
View Article and Find Full Text PDF[Experimental study of APB-DOCK8 transgenic tomato vaccine for caries prevention].
Shanghai Kou Qiang Yi Xue
December 2023
Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University. Zunyi 563000, China. E-mail:
Article Synopsis
- * SD rats were immunized with the vaccine, and results showed that those receiving a higher dosage (8 mL/kg) developed significantly more antibodies and had fewer caries compared to other groups.
- * RNA sequencing analysis revealed 40 genes with altered expression in vaccinated rats, with key pathways related to immune response being activated, including the PI3K-AKT pathway, suggesting the vaccine might work by enhancing these immune processes.
Chitosan as a biomaterial for the prevention and treatment of dental caries: antibacterial effect, biomimetic mineralization, and drug delivery.
Front Bioeng Biotechnol
September 2023
Hospital of Stomatology, Jilin University, Changchun, China.
Dental caries is a chronic, progressive disease caused by plaque, influenced by multiple factors and can damage the hard tissues of the teeth. In severe cases, it can also lead to the onset and development of other oral diseases, seriously affecting patients' quality of life. The creation of effective biomaterials for the prevention and treatment of dental caries has become one of the relentless goals of many researchers, with a focus on inhibiting the production of cariogenic plaque and retaining beneficial bacteria, guiding and promoting the reconstruction of dental hard tissues, and delaying the progression of existing caries.
View Article and Find Full Text PDFThe pH-responsive zeolitic imidazolate framework nanoparticle as a promising immune-enhancing adjuvant for anti-caries vaccine.
J Dent
March 2023
Center for Biological Science and Technology, Guangdong Zhuhai-Macao Joint Biotech Laboratory, Advanced Institute of Natural Sciences, Beijing Normal University, Zhuhai, China; Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing, China. Electronic address:
Objectives: Streptococcus mutans (S. mutans) is the main aetiologic bacterium of dental caries, whose protein antigen (PAc) has been administered as an anti-caries vaccine. In addition, several fusion proteins or PAc combined with adjuvants were used as anti-caries vaccines to improve the relatively weak immunogenicity of PAc.
View Article and Find Full Text PDFThe findings of glucosyltransferase enzymes derived from oral streptococci.
Jpn Dent Sci Rev
November 2022
Department of Pediatric Dentistry, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Glucosyltransferase enzymes (Gtfs) distribute among some streptococcal species in oral cavity and are known as key enzymes contributing to the development of oral biofilm such as dental plaque. In 18 streptococcal species, 45 glucosyltransferase genes () are detected from genome database. Gtfs catalyze the synthesis of the glucans, which are polymers of glucose, from sucrose and they are main component of oral biofilm.
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