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Pre-operative carcino-embryonic antigen prognosticates early disease-free survival following curative surgery for non-small cell lung cancer.
Med J Malaysia
November 2024
Sunway Medical Centre, Sunway Clinical Research Centre, Sunway City, Selangor, Malaysia.
Article Synopsis
- Serum carcinoembryonic antigen (CEA) is indicated as a valuable prognostic biomarker for recurrence and survival in patients with early non-small cell lung cancer (NSCLC) after curative surgery.
- The study involved 18 patients with early-stage NSCLC, measuring their serum CEA levels before and after surgical resection over a follow-up period, revealing that 39% had elevated pre-operative CEA levels.
- Results showed that patients with a baseline CEA level above 5.0 ng/ml had significantly poorer disease-free survival compared to those with lower levels, underlining the potential of CEA to identify patients at risk for worse outcomes.
Background: Preoperative accurate visceral pleural infiltration (VPI) diagnosis for T1-size non-small cell lung cancer (NSCLC) is significant for clinical decision-making. The study aimed to explore the diagnostic efficacy of computed tomography (CT) imaging features and serum biomarkers in diagnosing VPI in newly discovered subpleural NSCLC ≤3 cm.
Methods: There were 447 patients with NSCLC ≤3 cm retrospectively enrolled and assigned to the VPI group (n=81) and the non-VPI group (n=366) based on elastic fiber staining results.
Stability of ten serum tumor markers after one year of storage at -18°C.
Clin Chem Lab Med
July 2024
Laboratoire de Biochimie et Biologie Moléculaire, Centre Hospitalier Universitaire de Nîmes, Université de Montpellier, Nîmes, France.
Objectives: The storage of serum tumor markers (STM) at -18 °C for one year has been a legal requirement in France since 1999, but has been abolished in 2022. This raises the question of the relevance of maintaining these biobanks in terms of conditions of storage. These should only be implemented after validation; in order to maintain the integrity of the biological sample and must be controlled over time according to the laboratory's procedures.
View Article and Find Full Text PDFCyfra 21.1: A Useful Tumour Marker in Pancreatic Ductal Adenocarcinoma: Cross-Sectional Study.
Cancer Control
January 2024
Department of General Surgery, Government Medical College, Trivandrum, India.
Background: Pancreatic cancer is a challenging disease, often requiring invasive procedures for diagnosis. Reliable tumour markers are essential for ensuring early detection and better patient outcomes. Although Carbohydrate Antigen 19-9 is the most commonly used marker, it is marred by low predictive accuracy and high false positivity.
View Article and Find Full Text PDFInhibitory effects of the nanoscale lysate derived from xenogenic dental pulp stem cells in lung cancer models.
J Nanobiotechnology
December 2023
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 324025, Zhejiang, China.
Background: Lung cancer is a highly prevalent malignancy and has the highest mortality rate among all tumors due to lymph node metastasis. Bone marrow and umbilical cord-derived mesenchymal stem cells (MSCs) have demonstrated tumor-suppressive effects on lung cancer. This study investigated the effects of DPSC lysate on proliferation, apoptosis, migration and invasion of cancer cells were studied in vivo and in vitro.
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