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Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma.
Front Oncol
January 2025
School of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, China.
Multiple Myeloma (MM) is the second most common malignancy of the hematopoietic system, accounting for approximately 10% of all hematological malignancies, and currently, there is no complete cure. Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory role in the initiation and progression of tumors, involving various interactions such as lncRNA-miRNA, lncRNA-mRNA, and lncRNA-RNA binding proteins (RBP). Despite the significant clinical application potential of exosomal lncRNAs, research in this area still faces challenges due to their low abundance and technical limitations.
View Article and Find Full Text PDFDiagnostic dilemma for human immunodeficiency virus in a fatal case of acute myeloid leukemia.
Indian J Sex Transm Dis AIDS
December 2024
Department of Microbiology and Infectious Diseases, National HIV/AIDS Reference Laboratory, All India Institute of Medical Sciences, New Delhi, India.
National Human Immunodeficiency Virus (HIV) testing programs utilize antibody-based tests for confirming HIV diagnosis which has a diagnostic window period of 23-90 days. In Fiebig acute HIV Stage I-II, an individual has antibody-negative but RNA-positive test results. Here, we present a case of a 54-year-old complete remission acute myeloid leukemia patient, who was recently reported HIV negative by antibody-based tests used in National HIV testing programs.
View Article and Find Full Text PDFAberrant right renal perfusion from right internal mammary artery.
J Vasc Surg Cases Innov Tech
April 2025
Division of Vascular Surgery and Endovascular Therapy, University Hospitals Harrington Heart & Vascular Institute, Case Western Reserve University, Cleveland, OH.
Renal artery (RA) anomaly is common and may have significant clinical implications. We present a case of a 29-year-old man in whom the upper two-thirds of the right kidney were supplied by the right internal mammary artery and collateral network. Additionally, the superior left RA had proximal stenosis with a distal aneurysm.
View Article and Find Full Text PDFNovel proteomics-based plasma test for early detection of multiple cancers in the general population.
BMJ Oncol
January 2024
Novelna Inc, Palo Alto, California, USA.
Objective: Early detection of cancer is crucial for reducing the global burden of cancer, but effective screening tests for many cancers do not exist. This study aimed to develop a novel proteome-based multi-cancer screening test that can detect early-stage cancers with high accuracy.
Methods And Analysis: We collected plasma samples from 440 individuals, healthy and diagnosed with 18 early-stage solid tumours.
Dealing With Rape Cases in Ghana: The Law, the Victim and the Offender.
Sex Offending
December 2023
Narcotics Control Commission, Accra, Ghana.
Rape is a criminal offence in all countries of the world. However, what constitutes rape in the legal sense differs from country to country, with many common law countries sharing some similarities in their definition of rape. This paper conducts a critical review of the crime of rape in Ghana by discussing what constitutes rape under Ghanaian law, its key elements which a prosecution has to prove to succeed on a charge of rape, and the challenges of adjudicating rape cases in Ghana, paying particular attention to the victim.
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