AI Article Synopsis
- A study evaluated the effects of indometacin, carprofen, and a placebo on gastric juice secretion and prostanoid levels in nine healthy volunteers over three-day treatment periods.
- Indometacin was classified as a strong cyclooxygenase inhibitor, effectively reducing levels of PGE2, TXB2, and PGF-MUM both before and after stimulation.
- Carprofen showed weak inhibition of PGE2 before stimulation and none after, but had strong effects on TXB2, possibly explaining its lower incidence of gastric side effects compared to indometacin.
Article Abstract
The effect of indometacin (3 X 50 mg daily), carprofen (Imadyl) (2 X 150 mg daily) and placebo (3 X daily) on gastric juice secretion, acidity, prostanoid concentration (PGE2, PGF2 alpha and TXB2) and excretion of the major urinary metabolite of PGF (PGF-MUM) were investigated in a single-blind cross-over study in nine healthy volunteers after 3-day treatment periods separated by one-week washout periods between treatments. Indometacin proved to be a classical cyclooxygenase inhibitor (strong inhibition of PGE2 and TXB2 before and after pentagastrin stimulation and of PGF-MUM) while carprofen was an atypical inhibitor (weak inhibition of PGE2 before pentagastrin stimulation and no inhibition after, strong inhibition of TXB2 but without influence on PGF-MUM). The weak inhibition of PGE2-biosynthesis by carprofen might be related to its low incidence of gastric side effects.
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