Diffusion of enoxacin into the cerebrospinal fluid in dogs with healthy meninges and with experimental meningitis.

After a 1 h intravenous injection of 12.5 and 25 mg/kg enoxacin in dogs with healthy meninges, the concentrations in cerebrospinal fluid observed between 90 and 240 min averaged 2.6 (1.8-3.3) mg/l and 6.5 (4.7-8.4) mg/l respectively. In dogs with meningitis, a dosage of 12.5 mg/kg yielded a mean concentration of 4.9 (3.1-6.4) mg/l. The concentrations obtained in dogs with healthy meninges greatly exceeded the MICs for meningococci and Haemophilus influenzae. In the infected dogs, the concentrations obtained exceeded the MICs of the most common causative agents of meningitis. In the dogs with healthy meninges the ratio CSF/plasma AUCs was 47% after 25 mg/kg and 33% after 12.5 mg/kg. In the infected dogs, the ratio was 67.3% after 12.5 mg/kg.