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Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters.
Front Immunol
September 2023
Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Genogroup II (GII) noroviruses are a major cause of diarrheal disease burden in children in both high- and low-income countries. GII.17 noroviruses are composed of distinct genetic clusters (I, II, IIIa, and IIIb) and have shown potential for replacing historically more prevalent GII.
View Article and Find Full Text PDFBAP31, a newly defined cancer/testis antigen, regulates proliferation, migration, and invasion to promote cervical cancer progression.
Cell Death Dis
July 2018
Department of Immunology, the Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
Malignant tumors typically undergo an atavistic regression characterized by the overexpression of embryonic genes and proto-oncogenes, including a variety of cancer/testis antigens (CTAs) that are testis-derived and are not expressed or expressed in trace amounts in somatic tissues. Based on this theory, we established a new method to identify unknown CTAs, the spermatogenic cells-specific monoclonal antibody-defined cancer/testis antigen (SADA) method. Using the SADA method, we identified BAP31 as a novel CTA and confirmed that BAP31 expression is associated with progression and metastasis of several cancers, particularly in cervical cancer.
View Article and Find Full Text PDFRo52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.
J Autoimmun
May 2017
Dept. Medicine, Division of Rheumatology, New York University School of Medicine, New York, USA.
The detection of cardiac conduction defects in an 18-24 week old foetus in the absence of structural abnormalities predicts with near certainty the presence of autoantibodies against 60kD and 52kD SSA/Ro in the mother regardless of her health status. Previous studies have emphasized these autoantibodies as key mediators of tissue injury. The aim of this study was to focus on the anti-Ro52 response to determine whether these autoantibodies originate from progenitors that are inherently self-reactive or from B-cells that acquire self-reactivity during an immune response.
View Article and Find Full Text PDFCharacterization and expression of monoclonal antibody-defined molecules on resting and activated bovine αβ, γδ T and NK cells.
Vet Immunol Immunopathol
November 2015
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USA. Electronic address:
Monoclonal antibodies (mAbs) specific for leukocyte differentiation molecules (LDMs) were developed during the past few decades to expand reagents for research in ruminants, pigs, and horses. The specificity of some of the mAb-defined molecules was determined through participation in international workshops. Other molecules identified with mAbs during this time, and more recently with mAbs developed after the workshops, have remained partially characterized.
View Article and Find Full Text PDFMonoclonal Antibody-Defined Specific C Epitope of Brucella O-Polysaccharide Revisited.
Clin Vaccine Immunol
August 2015
INRA, UMR1282 Infectiologie et Santé Publique, Nouzilly, France Université François Rabelais de Tours, UMR1282 Infectiologie et Santé Publique, Tours, France.
The C epitope of Brucella O-polysaccharide (O-PS) has so far lacked definitive structural identity. Revised structures for this antigen revealed a unique capping perosamine tetrasaccharide consisting of a sequence of 1,2:1,3:1,2 interresidue linkages. Here, using synthetic oligosaccharide glycoconjugates, the α-1,3 linkage of the O-PS is shown to be an integral structural requirement of this epitope.
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