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Terrein: isolation, chemical synthesis, bioactivity and future prospects of a potential therapeutic fungal metabolite.
Nat Prod Res
December 2024
Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.
The increasing risk of drug-resistant infections and unexpected pandemics like Covid-19 has prompted researchers to explore the area of drug repurposing. Natural products, being a result of the evolutionary optimisation processes can be potential starting points for such drug discovery programs. One such unexplored chemical is terrein, a secondary fungal metabolite.
View Article and Find Full Text PDFBiomimetic green synthesis of ZnO nanoflowers using α-amylase: from antimicrobial to toxicological evaluation.
Sci Rep
July 2024
Department of Chemistry, Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates.
Biologically mediated synthesis of nanomaterials has emerged as an ecologically benign and biocompatible approach. Our study explores enzymatic synthesis, utilizing α-amylase to synthesize ZnO nanoflowers (ZnO-NFs). X-ray diffraction and energy-dispersive X-ray spectroscopy revealed crystal structure and elemental composition.
View Article and Find Full Text PDFSensing the Bactericidal and Bacteriostatic Antimicrobial Mode of Action Using Raman Deuterium Stable Isotope Probing (DSIP) in .
ACS Omega
June 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology Dharwad, Dharwad, Karnataka 580011, India.
The mode of action of antibiotics can be broadly classified as bacteriostatic and bactericidal. The bacteriostatic mode leads to the arrested growth of the cells, while the bacteriocidal mode causes cell death. In this work, we report the applicability of deuterium stable isotope probing (DSIP) in combination with Raman spectroscopy (Raman DSIP) for discriminating the mode of action of antibiotics at the community level.
View Article and Find Full Text PDFEngineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V.
Microbiol Res
May 2024
Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands. Electronic address:
Antimicrobial peptides (AMPs) show promise as alternatives to traditional antibiotics for treating drug-resistant infections. Their adaptability and diverse sequence possibilities allow for rational design by modulating physicochemical determinants to achieve desired biological properties, transforming them into peptides for potential new therapies. Nisin, one of the best-studied AMPs, is believed to have potential to be used as a therapeutic, particularly against antibiotic-resistant bacteria.
View Article and Find Full Text PDFAntimicrobial and anti-biofilm activity of a thiazolidinone derivative against and .
Microbiol Spectr
March 2024
Laboratory Medicine Center, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
() causes many infections with significant morbidity and mortality. can form biofilms, which can cause biofilm-associated diseases and increase resistance to many conventional antibiotics, resulting in chronic infection. It is critical to develop novel antibiotics against staphylococcal infections, particularly those that can kill cells embedded in biofilms.
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