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Compelling concerns about antimicrobial resistance and the emergence of multidrug-resistant pathogens call for novel strategies to address these challenges. Nanoparticles show promising antimicrobial activities; however, their actions are hindered primarily by the bacterial hydrophilic-hydrophobic barrier. To overcome this, we developed a method of electrochemically anchoring sodium dodecyl sulfate (SDS) coatings onto silver nanoparticles (AgNPs), resulting in improved antimicrobial potency.
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Biomacromolecules
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Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, Poland.
Cross-linking bonds adjacent polymer chains into a three-dimensional network. Cross-linked poly(vinyl alcohol) (PVA) turns into a hydrogel, insoluble structure exhibiting outstanding sorption properties. As an electrospinnable polymer, PVA enables the creation of nanofibrous hydrogels resembling biological tissues, thus ideal for nature-inspired platforms.
View Article and Find Full Text PDFA Polysaccharide-Calcium Carbonate Microsphere-Doped Hydrogel for Accelerated Diabetic Wound Healing via Synergistic Glucose-Responsive Hypoglycemic and Anti-Inflammatory Effects.
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Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Molecular Sciences, Henan Key Laboratory of Natural Medicine Innovation and Transformation, State Key Laboratory of Antiviral Drugs, Henan University, Kaifeng 475004, China.
As common complications of diabetes, long-term hyperglycemia and inflammatory infiltration often lead to prolonged unhealing of chronic diabetic wounds. The natural hydrogel-containing plant polysaccharides were recorded to have effective hypoglycemic and anti-inflammatory effects. This study focused on the accelerating effect of diabetic wound healing of hydrogels doped with polysaccharide (DOP)─calcium carbonate (CaCO) microspheres, which have glucose-responsive insulin release and anti-inflammatory effects.
View Article and Find Full Text PDFOn-demand release of insulin using glucose-responsive chitosan-based three-compartment microspheres.
Int J Biol Macromol
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Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
Various injectable glucose-responsive insulin release systems, including microspheres, have been developed to achieve insulin release for over a day. However, a major challenge is on-demand release insulin, which is closely related to the degradation rate of the delivery vehicle. Herein, chitosan-based three-compartment microspheres (TCMs) were fabricated using gas-shearing microfluidics.
View Article and Find Full Text PDFA 3D bioprinted potential colorectal tumor model based on decellularized matrix/gelatin methacryloyl/nanoclay/sodium alginate hydrogel.
Int J Biol Macromol
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Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China. Electronic address:
Colorectal cancer (CRC) is now the third most common cancer worldwide. However, the development cycle for anticancer drugs is lengthy and the failure rate is high, highlighting the urgent need for new tumor models for CRC-related research. The decellular matrix (dECM) offers numerous cell adhesion sites, proteoglycan and cytokines.
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